椎基底动脉迁曲扩张症病人发生脑微出血的影响因素

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[中图分类号]R734.9；R734.34 [文献标志码］A [文章编号] 2096-5532（2025）05-0679-04doi：10.11712/jms.2096-5532.2025.61.168 [开放科学（资源服务）标识码（OSID）][网络出版] https：//link.cnki.net/urlid/37.1517.r.20251120.1720.001； 2025-11-21 15：39：24

Influencing factrs fortheonsetofcerebral microbleeds inpatients with vertebrobasilardolichoectasiaDONG Xianming，QU Xin， LURuichun（DepartmentofPathology，TheAfiliated Hospitalof Qingdao University，Qingdao 266l0o，China）

[Abstract]ObjectiveTo investigate theinfluencingfactors fortheonsetandseverityofcerebralmicrobleds（CMBs）inpatientswith vertebrobasilardolichoectasia（VBD）.MethodsAtotalof132 patients who werediagnosed with VBDbymagnetic resonanceangiographyin Qingdao MunicipalHospitalfromJanuary20l9 toJune2O24 wereenrolled，andacording totheresults of magneticresonanceimagingandsusceptibility-weightedimaging，theywere dividedintoCMBs group with78patientsand non CMBs groupwith54patients.Relateddata werecolected fromallpatients，includingage，sex，historyofhypertension，historyof diabetes，historyofhyperlipidemia，historyofsmokinganddrinking，totalcholesterol（TC），triglyeride（TG），ow-desitylipo proteincholesterol（LDL-C），ighdensitylipoproteincholesterol（HDL-C），homocysteine，andD-dimer.Theinfluencingfactors fortheonsetand severityof CMBs were analyzed.ResultsThere were significant diferencesinsex，TC，TG，LDL-C，and HDL-C between the CMBs group and the non-CMBs group （ ⟨Z=2.33-3.26，χ2=6.98，P<0.05） . The possibility of CMBs in male VBD patients was 3.00 times that in female patients ⟨OR=3.00，P<0.05⟩ . Male patients with CMBs tended to have a more severe condition ⟨OR=2.27，P<0.05⟩ ，and the condition of CMBs aggravated with the increases in the levels of TG（ 0.05），TC（ OR=1.39 ， P<0.05 ），andLDL-C ⟨OR=1.52，P<0.05⟩ .ConclusionMale sex is an independent risk factor for CMBs，and malesex，TG，TC，andLDL-Care independentriskfactorsforthe severityofCMBs.Bloodlipidtesting should beperformed for patients with VBD in clinical practice to reduce the risk and severity of CMBs.

[Key words]vertebrobasilar dolichoectasia；cerebral hemorrhage；root cause analysis

椎基底动脉迁曲扩张症（VBD）是复杂的神经血管疾病，以椎基底动脉延长和扩张为特征[1-2]。（剩余6936字）