TRPV4通道在心肌纤维化中作用机制的研究进展

打开文本图片集

[关键词] 心肌疾病;纤维化;TRPV 阳离子通道;转化生长因子 1;肌成纤维细胞;信号传导;综述[中图分类号] R542.23;R329.25 [文献标志码] A [文章编号] 2096-532（2025）02-0308-04doi：10.1712/jms.2096-532.2025.61.05

[Abstract] Transientreceptorpotentialvaniloid4（TRPV4）canintegratesolublebiochemicalsignalsandmechanicalsignals andpromotethediferentiationofibroblastsintomyofibroblasts，therebyplayinganimportantroleinmyocardialfibrosis.ThearticlereviewsthelatestresearchadvancesinthemechanismofactionofTRPV4chanelsinmyocardialfibrosis.

[Keywords] cardiomyopathies;fibrosis;TRPVcationchanels;transforminggrowthfactorbeta1;myofibroblasts;signal transduction;review

心肌纤维化是多种类型心脏疾病的共同病理改变，由心脏细胞外基质（ ）过度积聚造成[1-2]。（剩余10962字）