不同剂量替格瑞洛对不同类型心绞痛病人疗效评价

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[中图分类号] R541.4;R972.7 [文献标志码] A [文章编号] 2096-532（2025）02-0243-04 doi：10.1712/jms.2096-532.2025.61.039

[Abstract]ObjectiveTo investigate theeficacyand safetyoflow-dose and standard-dose ticagrelorinthe treatmentof patientswithdiferenttypesofanginapectoris. Methods Atotalof216patientswithanginapectoriswhowereadmitedtoThe FirstHospitalofQinhuangdaofrom March2020toJune202 wereenroledassubjects，amongwhomtherewere12 patientswith stableanginaand94patientswithunstableangina.Acordingtothetreatmentmethodoflow-doseorstandard-doseticagrelor，the patientswiththetwotypesofanginapectorisweredividedintostableangina + standard-doseticagrelorgroup（groupAwith91patients），stableangina + low-doseticagrelorgroup （groupB with31patients），unstableangina + standard-doseticagrelorgroup （groupCwith64patients），andunstableangina+low-doseticagrelorgroup （groupD with30patients）.Theabovegroupswere observedintermsoftheserumlevelsofcardialtroponinI（cTnI），tumornecrosisfactor- ⋅α （TNF- ⋅α ），high-sensitivityC-reactive protein（hs-CRP），andinterleukin-6（IL-6）beforeandafter6monthsoftreatment，andtheeficacyandsafetyoftreatmentwere comparedbetwengroups Results Aftertreatment，algroupshadsignificantreductionsinTNF- α ，hs-CRP，IL-6，andcTnI （t=3.208-27.692，P<0.05） ，buttherewerenosignificantdiferencesintheseindicatorsbetwengroupsbeforeandaftertreatment ′F=0.159-2.492，P>0.05） ）.Therewerenosignificantdiferencesinoveralresponserateandtheincidenceratesofmyocardialinfarctionandcardiovasculardeathbetwengroupsaftertreatment ⟨X2=1.000-3.201，P>0.05⟩ ）.ComparedwithgroupsB andDaftertreatment，groupsAandChadatendencyofincreaseintheprobabilityofminorbledinganddyspnea，buttherewas nosignificantdiferencebetwengroups ⟨χ2=0.200-0.293，P>0.05⟩ ） Conclusion Low-doseticagrelorhascomparableeficacy tostandard-dosetherapyinthetreatmentofpatientswithdiferenttypesofanginapectoris，whichprovidesafeasiblealternative methodforthetreatmentofpatientswithdiferenttypesofanginapectoris.

[Key words] angina，stable;angina，unstable;ticagrelor; dose-resonserelationshi，dru ;validationstud ;dru-relatedside efectsandadversereactions

心绞痛是一种常见的心血管疾病，其临床特征为胸痛或不适，通常由冠状动脉供血不足引起[1-2]。（剩余6019字）