以癫痫大发作持续状态为首发症状的神经梅毒1例并文献复习

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[关键词] 神经梅毒;癫痫持续状态;脑脊髓液;基因检测;治疗结果;病例报告[中图分类号] R759.13 [文献标志码] B [文章编号] 2096-532（2025）02-0305-03

[Abstract] Objective Toinvestigatetheclinicalfeatures，diagnosis，andtreatmentofneurosyphilis. Methods Thisarticlereportedacaseofneurosyphiliswithstatusepilepticusastheinitialsymptomandperformedaliteraturereviewtosummarizeits athoenesis，clinicalsmtoms，imain findins，anddianosis. Results The atienthadthemainclinicalmanifestationof statuseileticus，withabnormalitiesonbothcranialmaneticresonanceimain andlon-termvideoelectroencehalorah .The metagenomicnext-generationsequencingofpathogensincerebrospinalfluididentified52sequencesofTreponemapalidum，witha relativeabundanceof 0.02% .Aftersymptomatictreatmentincludinganti-syphilisandantiepileptictherapies，thepatienthadsignificantimprovementsinclinicalsymptomsatdischarge. Conclusion Neurosyphiliscanhavevariousclinicalforms，anditiscrucialtomaintainvigilanceinclinicalpracticetoavoidmisdiagnosisandmistreatment.

[Keywords] neurosyphilis;statusepilepticus;cerebrospinalfluid;genetictesting;treatmentoutcome;casereports

神经梅毒是苍白密螺旋体（又称梅毒螺旋体）侵袭中枢神经系统所致的慢性临床综合征，脑、脊髓、周围神经等均可受累。（剩余5055字）