葛根素治疗代谢综合征作用机制研究进展

打开文本图片集

[关键词]葛根素；代谢综合征；肥胖；糖尿病；胰岛素抵抗；氧化应激；炎症 [中图分类号]R285 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.11.030

Research progress on the mechanism of action of puerarin in treating metabolic syndrome

CHEN Rui， XU Minjun， LU Yunbo， YUAN Yingqi， CHU Tongfei， CHENG Long* DepartmentofChineseMedicineandPharmacognosy，ChinaMedicdl University，Shenyang，Liaoningl1Ol22，China

[Abstract]Metabolicsyndromeisaclinical syndromecharacterizedbytheclusteredoccurrnceofobesitydiabetes， dyslipidemiahypertensio，hyperuricemiaandfatyliverdisease.Itspatogenesisinvolvesmultiplelinks，ncludingisulin resistane，chroicinflammation，oidativestrs，intestialmicrobiotaimbalane，andasulardsfunctioamongtesuain anactiveingredentextractedfromGegen PuerariaeLobataeRadix）posessesfunctionssuchasloweringbloodglucose，iproving insulinesistancedilatingbloodvessels，modulatingintestinalmicrobiotaexertinganti-inflammatoryffects，andcombating oxidativer.Itaptictsasinityeteseside andfatyliver，servingasakeycomponentinthetreatmentofmetabolicsyndrome.Thisarticlesystematicallyreviewsthe mechanismofactionofpuerarininthetreatmentofmetabolicsyndrome，providinginsightsforitsclinicalapplicationandfurther in-depth research.

[Keywords]puerarin；metabolicsyndrome;obesity；diabetes；insulinresistance；oxidative stress;inflammation

代谢综合征（metabolicsyndrome，MetS），又称内分泌代谢疾病，是指人体的糖、脂肪、蛋白质等物质发生代谢紊乱的病理状态，可导致多种疾病出现，以肥胖、胰岛素抵抗、血脂异常、高血压、高尿酸和脂肪肝等症状合并出现为特点。（剩余15532字）