基于外泌体-细胞衰老交互作用机制探讨中药复方抗动脉粥样硬化的研究进展
[关键词]动脉粥样硬化；外泌体；炎症-衰老循环；细胞衰老；病理机制 [中图分类号]R259 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.11.029
Research progress on anti-atherosclerotic effects of Chinese medicine compound formulas based on the interaction mechanism between exosomes and cellular senescence
YUAN Ye I，Z，s ， YU Hairui， HUA NGFU Haiquan4， LIU Yiwen5， LIU Caihui’， ZHAO Gang²， FAN Zengguang³* 1. Jixi People'sHospital Medical Group，Jixi， Heilongjiang158119，China;2.Heiongiang UnversityofChineseMedicine， Harbin，Heilonjiang5oina;3.heAfiatedHospitalofgxi Uivesityofinseedicine，NchangJgxi 330006，China;4henzhenuohuHspitalfraditiondlChineseedicinehenzhenGuangdong80oOChina;5.Jgi University of Chinese Medicine， Nanchang， Jiangxi 330o04， China
[Abstract]The "inflammation-senescencecycle"formedbyexosome-mediatedintercelularcommunicationandcellular senescencerevealsteorepathologicalmchansmofatheroslerosis（ASTisudysystematicallyombdtheinteractionmasms betweenexosomesandcelularsenescenceintheprogresionofAS.Ononehand，exosomesreleasedbysenescentcelscan cayinflmatorceotedeyedbsincall andsenescencephenotypeconversioninadjacentcels，，therebyexacerbatingtheinflammatorystateofthevascularwall.On theotherhand，exosomessecretedbydamagedvascularendothelialcell，macrophages，etc.，canfurtheractivatethecelular senescencepathwaysbyregulating thetransmisionof signaling moleculessuchasmicroRNAsandproteins，formingavicious cycle.Thissynergisticpathogenicpaternplaysakeyroleinmultiplepathologicalprocessesincludinglipidmetabolism disorder，vascularendothelialinjury，andplaquestabityimbalanceMeanwhile，thispapersystematicallyintegratedrelevant researchevidenceintheinterventionofASbyclassicChinesemedicinecompound formulas，suchas Huangqi GuizhiWuwu DecoctionandXuefuZhuyuDecoction.Itisfoundthattheseformulascaninterveneinkeylinksofthe"inflammationsenescencecycle"byregulatingthecompostionofexosomalcontents，blocking the transmisionofsenescencesignaling pathways，anddownregulatingtheexpresionlevelsofSASPfactorsthusprovidingascientifictheoreticalreferenceforCiese medicine to intervene in AS based on this cycle mechanism.
[Keywords]atherosclerosis； exosome;inflammation-senescencecycle;cellarsenescence;pathological mechanism
动脉粥样硬化（atherosclerosis，AS）是心脑血管疾病的核心病理基础，属于中医学“脉痹”“胸痹"范畴，核心病机为本虚标实、痰瘀互结。（剩余20471字）
