基于“态靶辨证”探析补肾开玄通络法治疗糖尿病肾病

打开文本图片集

[关键词]态靶辨证；糖尿病肾病；补肾开玄通络法；靶方；靶药 [中图分类号]R277.5;R259 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.11.016

Treatment of diabetic kidney disease with kidney-tonifying， mysterious mansion-opening， and collateral-unblocking therapy based on "state-target pattern identification"

XU Miaol2， LIU Zehao'， LIU Tonghua’， GAO Ming³， QIN Lingling'， WANG Haiyan'， LYU Cuiyan2* 1.Beijing Universityofhineseedicine，Beijingo29，China;2.BeijingHspitalofraditionalChineseMedicineCapital Medical University，Beijingo，China;3.Mukogma Women'sUniversity，NishinomiyaHyogo66-88，Japan

[Abstract]Diabetic kidneydisease（DKD），oneof the prevalentcomplicationsof diabetes，hasbeen innovativelyaddressed throughthe“state-targetpattrnidentification（STPI”theoreticalframeworkproposedbyAcademicianTONGXiaolin.This “macroscopicstateandmicroscopictarget”integratedChinese-Westerdiagnosticherapeuticmodelfectivelyaleviatesclinical symptomssuchasedema，fatigue，andfrothyurineinDKDpatients，therebyprovidingnovelinsightsforclinicalmanagement. Buildingonthe“mysteriousmansionofkidneycolateral”theoryandclinicalpractice，ourteamhasidentifiedathree-stage evolutionaryof“dfasis，drbituringgessooesoinglyvelodng mysteriousmasioopeningndcolteralunblockingterapymingtoiseasetaget，smptomargetandidicatoageis therapyemphasizespaten-diseasecombinationandsimultaneousstate-targetregulation，enablingstratifiedprecisioninteetio. Clinical evidencedemonstratesthat STPI，throughorganicintegrationofTCMholisticregulationandwesterntargetedtherapy， exhibits unique advantages in symptom improvement and renal function preservation in DKD.

[Keywords]state-target paternidentification;diabetickidneydisease;kidney-tonifying，mysteriousmansion-opening，and collateral-unblocking therapy; target formula; target medicine

作为糖尿病最严重的慢性并发症之一，糖尿病肾病（diabetickidneydisease，DKD）在临床中具有重要地位，同时也是诱发终末期肾病（end-stagere-nal disease，ESRD）的首要危险因素[]。（剩余12032字）