基于“微生物-肠-脑轴"浅析“脑肠同治"防治溃疡性结肠炎

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[关键词］溃疡性结肠炎；微生物-肠-脑轴；脑肠同治；中医药；肠道微生物；分期治疗 [中图分类号]R259 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.07.029

[Abstract]Thepathogenesisofulcerativecolitis（UC）remainslargelyunclearwithclinicalmanifestationsprimarilycharacterized byabdominalpaindiareandmucopulntbloodystols.UCisnotorousldiiulttoure，pronetourencandfollwsa chronicourse.Modernresearchhasrevealedthatdysfunctionof themicrobiota-gut-brainaxis（MGBA）playsa pivotalroleinthe pathophysiologyofUC.TheTCMtheoryof"simultaneoustreatmentofbrainandgut"highlycorespondswiththebidirectional regulatorymechanismsoftheMGBA，positingthat"liverstagnationwithspleendeficiency"causedbyemotionaldysregulationacts asthecorepathologicallinkconnectingpsychological stresswithintestinalinflammationandMGBAregulationBasedonthis theory，thisstudysystematicallelucidateshowTCMemploysstrategiessuchas"sothingtheliverandrectifyingthespleen， regulatingemotions"and"stagedtreatment，reinforcingaltyitoliminatepathogenicfactors"tointerveneatmultipleagets. Theseapproachesmodulateintestinalmicroeologytheneuroendocrineimmuneetwork，andintestinalbarierfunctionthreby achieving holisticregulationof the MGBA.Theaimis toprovidenewinsightsand methodsforthepreventionandtreatmentof UC.

[Keywords]ulcerativecolitis;microbiota-gut-brainaxis;simultaneous treatmentofbrainandgut; Chinesemedicine;gut ticrobiota; staged treatment

溃疡性结肠炎（ulcerativecolitis，UC）是一种目前发病机制尚未完全明确的非特异性炎性疾病，临床以腹痛、腹泻、黏液脓血便为主要症状，其特征是反复发作和缓解的肠道黏膜炎症，具有病程长、易复发、难治愈的特点。（剩余14058字）