孙氏腹针区穴位埋线结合重复经颅磁刺激治疗轻中度阿尔茨海默病的临床疗效研究

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[关键词］阿尔茨海默病；孙氏腹针区；重复经颅磁刺激；穴位埋线；多奈哌齐；认知功能；生活能力中图分类号]R255 [文献标志码]B [文章编号]doi：10.3969/j.issn.1674-070X.2025.07.011

Clinical efficacy of catgut-embedding therapy in SUN's abdominal acupuncture zone combined with rTMS stimulation in treating mild to moderate Alzheimer's disease

FAN Chengxin'， WANG Songyang²， MA Shuai'， ZHANG Miao1*

1.TheSecondDepartmentofAcupuncture-moxibustion，theSecondAfliatedHospialofHeilongjiangUniversityofChinese

Medicine，HarbnHilongjiang5o，hna;2.Gduatehol，HeilongiangUniversityofinseedicneHrbin Heilongjiang 150040， China

[Abstract]Objective Toobserve theclinical eficacyofSUN'sabdominal acupuncture zone pointcatgut-embedding therapy combinedwithrepetitivetranscranialmagneticstimulation（rTMS）intreatingmildtomoderateAlzheimersdisease（AD）.Methods Atotalof6OpatientswithmildtomoderateADwhovisitedtheacupunctureoutpatientclinicoftheSecondAfiliatedHospitalof Heilongjiang UniversityofChineseMedicinefromApril2O23toMay2O24wererandomlydividedintoanobservationgroup （n=30） and a control group （ n =30）.Both groupsreceived oral donepezil hydrochloride as the basic treatment.The control group received rTMS，whiletheobservationgroupreceivedaditionalcatgut-embedingtherapyasacupointsinSUN'sabdominalacupuncture Zone.Theacupointsselectedwere"Abdominalzone1"and"Abdominalzone8".Bothgroupsunderwent reatmentfor8weeks.The mini-mentalstateexaminon（MMSE），Montrealcognitiveassessmentscale（MoCA），andactivitiesofdailylivingcale（ADLsors werecomparedbetweenthetwogroupsbeforeandaftertreatmenttoevaluatetheclinicaleficacyandadversereactionsof both groups.Results Comparedwiththepre-treatmentstate，the MMSE，MoCA，andADLscores inbothgroupsincreasedaftertreatment L P <0.01），with the observation group showing higher scores than the control group （ P <0.05）.The overall clinical efficacy rate in the observation group （86.67% ）washigher than that in thecontrol group（ 76.67% （ P- <0.05）.No adverse reactionswere observedin either groupduring treatment ConclusionSUN'sabdominalacupuncturezone threadembeddingcombined withrTMScan ffectively improve cognitive function and daily living abilityin patients with mild to moderate AD.

[Keywords]Alzheimer'sdisease；SUN'sabdominalacupuncturezone；repetitive transcranial magneticstimulation;catgutembedding therapy; donepezil; cognitive function; daily living ability

阿尔茨海默病（Alzheimer's disease，AD）是导致痴呆的主要原因之一，其发病隐匿且持续进展。（剩余6902字）