基于“脾肾相关"理论探讨肌肉减少症与代谢相关脂肪性肝病的相关性

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[关键词]肌肉减少症；代谢相关脂肪性肝病；脾肾相关；脏腑理论；代谢性疾病；理论探讨 [中图分类号]R256 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.07.021

[Abstract]Metabolicasociated fatty liverdisease （MAFLD）has become oneofthe most common chronic liver diseases worldwideandoftencoexistswithsarcopeniaThetwoconditionssharemanycommonalitiesintheirpathogenesis，amongwhich insulinresistanceisegadedasthecoredrivingfactor.Addionalyhroniciflammatoryresponses，mitochondrialdfuction andgutmicrobiotadysbiosisalsocriticallyimplicatedinthepathogenesisndprogressonof theseconditions.Emergingevidence fromtheliteraturesuggestsacomplexbidirectionalpathophysiological interplaybetweensarcopeniaandMAFLD.InChinese medicine，itisasertedthat"theidneygovemsboneandmarrow，"thespleengoversthemuscles"，andtheidneyonstiutes theinnatefoundationandthespleenservesastheacquiredfoundationofvitality.Basedonthe"spleen-kidneybeingrelated" theory，thisstudyivestigatesthebidirectionalrelationshipbetwensarcopeniaandMAFLDanalyzesthemechansmsuderlying theircomorbidityfromboth ChineseandWestemmedicalperspectives，andsummarizestheprinciplesofpaterndiferentitionand treatment aiming to advance precision medicine approaches for related prevention and treatment strategies.

[Keywords]sarcopenia; metabolicassociatedfatyliverdisease;spleen-kidneybeingrelated;zang-fuorgantheory;etabolic diseases；theoretical discussion

肌肉减少症（sarcopenia）简称肌少症，以骨骼肌质量与年龄相关的衰退，以及肌肉力量和/或身体机能的低下为特征[1-2]。（剩余13329字）