基于“血脉癯积”理论探讨动脉粥样硬化铜死亡机制的中医病机及辨治策略

[关键词]动脉粥样硬化；血脉瘢积；铜死亡机制；“虚、瘀、毒"病机；补虚逐瘀法；活血解毒法;软坚消法 [中图分类号]R256.2 [文献标志码]A [文章编号]doi：10.3969/j.issn.1674-070X.2025.07.019

[Abstract]Atherosclerosis （AS）isavascularpathologicalconditioncharacterizedbychronic inflammatoryresponses. Cuproptosis，aforofcelldeathinducedbyexcessiveintracellarcopperionacumulationiscloselyassociatedwitheset andprogressionofAS.ItparticipatesinASdevelopmentbypromotinglipiddepositioninflammatoryinfiltrationabomal proliferationofsmothmuselecells，andoxidativestressreactions.Basedonthetheoryof"bloodvesselstagnationand accumulation"ourteamproposesthatthepathogenesisofASinvolvesdeficiencyofYuan-primordialqi，leadingtobloodstasis;

prolongedstagnationtransforingintotoxins，causingpathologicalchanges;andtheconglomerationofstasisandtoxins，esultingin theformationofaccumulations.GuidedbythistheoryandintegratingthemechanisticroleofcuproptosisinAS，atherapeutic aproachisadvocatedfortreatingAS，whichinvolvestonifyingdeficiencyandeliminatingstasis，activatingbloodirculatioto removetoxins，andsoftening hardnessandresolvingaccumulations.Thisstudytakes"bloodvesselstagnationandaccumulation"as theentrypoint，elucidatestheTCootatiosofuproptosismechanismsinASudertedanceofth"deficiencysis toxin"theoryandexploresTCMdiagnosticandtherapeuticstrategies.Theaimistoprovidetheoreticalfoundationsand differentiated treatment strategies for TCM interventionsin AS.

〔Keywords]atherosclerosis；bloodvessel stagnationandaccumulation;cuproptosismechanism；pathogenesisof"deficiency，stasisandtoxin”；tonifyingdeficiencyandeliminatingbloodstasis；activatingbloodciculationtoremovetoxins;softening hardness and resolving accumulations

动脉粥样硬化（atherosclerosis，AS）是一种复杂的血管病理过程，其核心特征表现为持续的慢性炎症反应。（剩余15277字）