慢性疼痛共患抑郁症的研究进展

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[Abstract]Depressionand chronic pain frequentlycoexistandare referredtoas comorbid depresive symptoms inchronic pain.Thiscomorbidityintensifiesthepatient’scondition，leading toprolongedandmoreintensepain，andmarkedlydiminishingthe patient'squalityoflife.Complexpysiologicalandpathologicallinksexistbetweendepressonandchronicpain，involvingumerous neurotrasmitersandseveralcriticalbrainareas.Moreover，theneuronalnetworksandthebrain’srewardsystemfrequentlyehibit dysfunctioninthesepatients，leadingtoanhedoniaanddiminishedmotivation.Notwithstandingadvancementsinphamacotherapynd painmanagementstrategiesfordepresiontheeficacyoftreatmentsforomorbidonditionsdiseasescontiuestobeconstraindExistingtherapymodalitiespredominantlyfocusonndividualdiseassndinadequatelytackleteintricaciesofcomorbidities.Tisevie aimstosystematicallyexamiethepathophsiologicalmechanism，eurotransmiterinvolvement，andnuralcicuitdyamicsofcoo biddepressivesymptoms inchroicpain，whilealsoexploringpotentialfutureresearhdirectionandtreatmentstrategiestoehance clinical interventions.

[Key words] Comorbid depressive symptoms in chronic pain；Neural circuit，Brain reward system，Neurotransmiter

慢性疼痛与抑郁症是两类常见且具有高度共病性的问题，影响全球数百万人的生活质量。（剩余13788字）