慢性炎症与衰弱的研究进展

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Research advances in chronic inflammation and frailty

Deng Ruibing1，Wang Xiaoming²，Zhang Wei1，Jin Ying1，Jia Xin² ** 1 DepartmentofGeriatricMedicieofirFrceMedicalCenterAirFceMedicalUniversityBeiing42;DepartmentofGeraricedie of Xijing Hospital，Air Force Medical University，Xi'an 710032 ** Corresponding author：Jia Xin，email：qianhao0916@163.com

[Abstract]Chronic inflammationandfrailtyhaveemergedaskeyfocalpointsinthefieldofgeriatricmedicine.Thisreview summarizestheresearchprogressonchronicinflammationandfrailty，encompassingdefinitionsandassessmentmethodsoffrilty， mechanisticdiscussionsontheirinterplay，andadvancesinkeyinflammatorybiomarkerssuchasCreactiveprotein，inteleukin-6， tumorecrosisfactor-alpha，andbiomarkerpanels.Thereviewims toprovideatheoreticalfoundationforestablishingpreventionand interventionsystemstargetingfrailtythoughiflammation-modulatingstategies，anditasimporantcliicalguidingsignificancfor improving the health prognosis of the elderly.

[Key words] Chronic inflammation；Frailty；C-reactive protein；Interleukin-6；Tumor necrosis factor- αααααααααααααααααααααααααα ；Biomarker panel

随着全球人口持续老龄化，衰弱已成为全球公共卫生的一个重大问题。（剩余12703字）