痒螨病皮肤损伤机制研究进展

打开文本图片集

中图分类号：S855.9 文献标志码：A 文章编号：0366-6964（2025）07-3142-10

Abstract： Psoroptic mange， a prevalent ecto-parasitic disease affecting domestic and wild animals globally，is primarily characterized by skin lesions. Understanding the characteristics and mechanisms underlying these skin lesions is crucial for developing novel measures against psoroptic mange. This paper systematically reviews the pathological manifestations of skin lesions in psoroptic mange，focusing on the perturbations in the skin’s physical and immune barriers during disease progression. Potential factors contributing to these alterationss are discussed，including the mechanical activity of Psoroptes mites and their excretory-secretory proteins （PsoES） which can impair the skin's physical barrier. Additionally，allergenic and other bioactive molecules within the PsoES can infiltrate the weakened physical barrier，disrupting the immune barrier and thereby accelerating the onset and and progression of skin damage. The objective of this review is to provide insights and directional guidance for the development of novel anti-mite therapeutics，ultimately aiming to provide new perfectives on the prevention and control of psoropic mange.

Keywords：psoroptic mange;skin lesion；causative factors of skin lesion ∗ Corresponding author：GU Xiaobin，E-mail： guxiaobinl98225@126.com

痒螨病是流行于全球家养动物（以绵羊、水牛和兔为主）和野生动物（骆驼、野生大角羊等）的常见外寄生虫病，该病由绵羊痒螨（Psoroptesouis）所引起，造成动物生产性能下降，若不及时治疗可引起死亡[]，给家养动物养殖业带来巨大经济损失，同时还对野生动物的生存构成威胁[2]。（剩余19783字）