阿胶和阿胶肽对血管内皮细胞氧化损伤的作用研究

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关键词阿胶；阿胶肽；过氧化氢；人脐静脉内皮细胞；氧化损伤

中图分类号R285文献标识码A

文章编号 0517-6611（2025）08-0162-06

doi：10.3969/j.issn.0517-6611.2025.08.035

开放科学（资源服务）标识码（OSID）：

Abstractbective]Toaalyeteoleoforiollini（Ejia）adEjpeptideinoxidatiestressijuyofscularedothelialcels andthemechanismoftheirrole.[Metod]Themodelofhumanumbilicalveinendothelialcellinjuryinducedbyhydrogenperoxide（ ） wasestablishedTetsofEjaodEjapeptideontesurvialateofumanmblcalvendothelialcs（HUVEC）beforeadfter modelingweredteedbyCCK-8eeectsofEjandEjaopeptideonthactitiesofcellsuperoxidedsmutase（SOD）glutatioepe oxidase（GSH-px），lactatedehydrogenase（LDH）andtecontentsofalondialdehde（MDA）ascuarendthelialgrowthfctor（EGF）， interleuki-6（-6）ricide（NO）reded.esultEdEpeptidouldectivelyproteeproliferatiodo of HUVEC，and could effectively resist the proliferation inhibition caused by oxidative injury. Ejiao and Ejiao peptide could significantly inhibit the excessive production of MDA and LDH， Ejiao could significantly increase the enzyme activity of GSH-px，Ejiao peptidecouldsignificantlyincreasetheexpressonlvelofSODandrepirteoidativeijuyofHUVCBothEjiaoadEjapeptideould effectivelyproefyulardolpottsdelalfucioteeoVGy vascularendoelialelluceotf6ooteogsisduceatoactoocisf EjiaoandEjioeptideducinoidativestressofECabelatedtprovingcellgrowhndproliferatiohncingeltioidantenzymeactivityrotigtexpresiofsredoelialgowthfctorandprootigtesetioofbasadelal cells.

Key wordsCorii colla asini（Ejiao） ；Ejiao peptide；Hydrogen peroxide ）； Human umbilical vein endothelial cells（HUVEC） ；Oxida-tive injury

由于当今世界的人口日益老龄，许多慢性疾病如冠状动脉粥样硬化、糖尿病和脂肪肝的患病比例正在不断上升[1]与高血压、高血脂、衰老等疾病密切相关的血管内皮细胞功能的损伤研究逐渐引起人们的重视[2]。（剩余10719字）