沙库巴曲缬沙坦规范化治疗心力衰竭效果观察

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Observation on the Effect of Valsartan and Sacubactril in the Standardized TreatmentofHeartFailure

WANG Tianlu （LiangzhouHospital，Wuwei City，Gansu Province）

Abstract：Objective：To investigate the effect of sacubactril valsartan in the treatment of heart failure.Methods： A totalof80patients withheartfailure admited toLiangzhouHospital，Wuwei City，GansuProvincefromJanuary023 to December2O23 were selectedanddivided into thecontrol groupandthe study groupbyodd-even table method，with 40 cases in each group.The control group receivedconventional treatment，and the study group received standardized treatment with sackubactril valsartan onthe basis of the control group.Theclinical efcacy，adverse reactions and cardiac function indexes were compared between the two groups.Results：The clinical effect of the study group was better than that of the control group （P<0.05） .There was no significant difference in the incidence of adverse reactions among different groups （P>0.05） ）.After treatment，the left ventricular ejection fraction of the study group was higher thanthatof the control group，and the serum N-terminal brain natriuretic peptide precursor，angiotensin Iand matrix metalloproteinase-9 of the study group were lower than those of the control group （P<0.05） ）.Conclusion：Standardized treatment ofsakubatrol valsartan in patients withheart failure is efective and safe，and can improve heart function.

Keywords：heart failure;sacubactril valsartan;efficacy;standardized treatment

0 引言

心力衰竭是冠心病、心肌梗死等多种心脏疾病导致的心功能下降、心脏收缩和（或）舒张功能障碍，心排血量减少无法满足身体组织代谢需求，常见症状包括气促、心悸、乏力等[。（剩余3149字）