桑菊饮颗粒剂的制备及4种化学成分的含量测定

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【中图分类号】R284.1 【文献标志码】A 【文章编号】1007－8517（2025）12-0039-06

DOI： 10.3969/j .issn.1007-8517.2025.12.zgmzmjyyzz202512010

Abstract：ObjectiveToexplore thepreparationprocessofSangjuYingranulesandestablishahigh-performanceliquidchromatography（HPLC）metodforsimultaneousdetemnationfchrogenicaid，uteoloside，utinandpllyincontentinSngjuYin granules.Methods Prepare Sangju Yingranulesthroughwet granulationprocess；HPLCmethodwasused todeterminethecontentsof chlorogenicacid，luteoloside，rutin，and philyrin in SangjuYingranules.The chromatographic column wasODS -C18 column，and the mobile phase was acetonitrile 0.4% phosphoric acid water. Gradient elution was performed with a volume flow rate of 1.0mL/min The column temperature is 30qC ，the detection wavelengths are 348 nm and 277 nm，and the injection volume is 5μL .Results The preparation process of Sangju Yin granules is Sangju Yin extract： corn starch： sucrose .The obtained granules have a light brownappearance，uniformparticlesize，onsistentcolor，andgodsolubilityTelinearrangesofchlorogeniccid，uteolosdeu tin，and phillyrin are 7.03-140.67μg/mL 6.40-128.00μg/mL ， 6.03-120.67μg/mL ，and 5.87-117.33μg/mL ，respectively，withcoelatiocoeficints（r）of.9998，.9998，.98，and1，spctively；everagesampleecoeryateswer 101.09v% ， 100.98% ， 99.34% ，and 100.34% ，respectively，with RSDsof 1 60% ，1. 87% ， 2.67% ，and 2，40% ，respectively. ConclusionsThepreparationprocessofSangjuYingranulesisstableandfeasible，andthemethodsfordeterminingthecontentsof chlorogenicacid，uteoloside，rutin，andphilyrinareacurateandreliable，whichcanbeusedforqualitycontrolofteales.

KeyWords：Sangju Yin Granules；HPLC；Chlorogenic acid;Luteoloside；Rutin；Phillyrin

桑菊饮为中药传统复方，属辛凉解表之轻剂，源于清代温病学家吴鞠通所著《温病条辨》卷一上焦篇，书中记载“此辛甘化风，辛凉微苦之方也”[1]。（剩余5754字）