基于文献挖掘的慢性盆腔炎动物模型应用分析

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中图分类号：R271.1 文献标识码：A文章编号：1006-1959（2025）09-0042-08

DOI：10.3969/j.issn.1006-1959.2025.09.007

Abstract：OetieTideethodcaleferefompingtesatefodeligauatihfetivef drugsbystudgodeligetddosaatideeementsofalodelsofoccfatseesWh “chronicpelviciflammatorydisease”and“animalmodel"asthekeywords，databasessuchasCKI，WanfangPubmedandWebfienc（Wo） wreearchiasiodda establishandprocssthatabasdoolsedodlndsyctofoodelidodelracteritied ResultsA total of 133 articles were included，of which180-240 δ g female SD rats were the most widely used experimental animals.The most commonly used modeling method was bilateral intrauterine injection of 25 % phenol mucilage.The modeling time of mixed bacterial infection method andhemicalgdsostldaistratieofdcterlfetioethasostlaysdsttio cycleofchmicalngetodasostl4dastholntieodaceetetodasanddse was21days.The high-frequencydetection indexes wereHEstaining toobserveuterine tissepathologyandserum TNF- ∇⋅ αα. ，IL-6，IL-1β levels，etc.， andthclustergolddivdtotegeConusioeistiialoelsofcelvicmatosasaostlygl factorodelsafdeleaosisropsieCelfeaddi Chineseandoudabdcsiifelottac Key words：Chornic pelvic inflmamatorydisease; Animal model; Data mining; Application analysis; Biochemical index

慢性盆腔炎（chornic pelvic inflmamatory dis-ease，CPID）是女性生殖器官及周围结缔组织、盆腔腹膜发生的慢性炎性病变，以输卵管炎、卵巢炎最常见，临床主要表现为下腹疼痛或坠胀感、白带异常或增多、腰骶部酸痛、月经不调等，多见于育龄、性行为活跃的年轻女性，年龄一般为18＼～25岁，发病率高达 3 0 % 。（剩余7745字）