基于生物信息学的阿尔兹海默病线粒体相关Hub基因的筛选

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中图分类号：R749.1 文献标识码：A文章编号：1006-1959（2025）09-0001-07

Abstract：OeiTeihodalbodissfoatilsdalctio. MethodsTeAeimersdseasegenechipdatasetasdowloadedfrotheGEOdatabaseoftheNatioalCenterforBiotechologInfotion theUnitedStateeubsoferiseaseesedtouhdieretialexpresoaalysisdweightednpon networkaalysiseitoondialrelatedgnsraidfroteitCarta3dtabasedinterseedittforemetiodubees. Theintersectiongnsweeechedandaalyed，andaproteininteractioetworkaonstructedusingteStringdtabase.Tesulsre importedintoCytoscapesoftwareandtetop6gnsrankedinDegrewerescrendusingtheCCalgorit.ResultsAtotalof38down regulatedgenesdaedseedetialexpressolotalofseeyde co-expressooalysdolddioaGtal showedthatitasainlyolediloicalroceuchsangsiniochodrialorpeplicatioofiocodalo synthesisfniochodrialompoentsnditocondialaterialtrasportKGGpathaichentalysissodatitsinly enrichdnaroo‘scidabdsttaboallod relatedtoAlzier‘sseaseereeedbCyaesoftare：C，UFABPOosioo Alzheimersdiseaseenetasdobidwirityoffoatialsetosiitohodralubnsetied which can provide atheoretical basis for the role of mitochondrial dysfunction in Alzheimer's disease.

Keywords：Bioinformatics;Alzheimer'sdisease;Mitochondria;Hub genes

阿尔兹海默病（Alzheimer'sdisease，AD）是一种常见于老年和老年前期的中枢神经系统退行性疾病，以进行性认知功能障碍和行为损害为主要特征，临床上以性格改变、幻觉、妄想、猜疑和情绪不稳等精神症状为表现I。（剩余11556字）