不同浓度阿托品对近视病儿视力和双眼调节功能影响

打开文本图片集

[中图分类号]R778.11；R996 [文献标志码]A [文章编号] 2096-5532（2025）04-0598-05

doi：10.11712/jms.2096-5532.2025.61.126

[Abstract]ObjectiveToinvestigate theefectofdiferent concentrationsof atropineeyedropsonspherical equivalentre fraction（SER），axial length（AL），pupil diameter（PD），andamplitudeof acommodation（AMP）in children with myopia. MethodsAtotalof150children withmyopia who were admitedtoHengshui People’s Hospital fromJanuary 202oto January 2022 were enrolled and randomly divided into 0.1g/L atropine group （control group） and 0.2g/L atropine group （observation group）inadouble-blind manner，with75children in each group.Allchildren receivedonedrop foreach eyeat night，and the course of treatment was 2 years forboth groups.SER，AL，PD，and AMP were measured every4 months.The repeated measures analysisofvariancewasused toassessthelongitudinalchangesofeachparameteratdiferenttimepoints，whiletheMann-Whitney （ U test wasused forcomparison between groups.ResultsAfter 2 yearsof treatment，there were significant diferences in the changes in SER and AL between the two groups （Z=2.17-2.39，P<0.05） ，suggesting that compared with the control group，the observation grouphadslowerprogresioninmyopiaandalowerdegreeofaxialelongation.ThechangeinALwassignfcantlyne gatively correlated with that in SER （β=-1.42，95%CI=-1.61 to -1.21，P<0.05） . There were no significant differences in the changes in SER and AL between the first and second years of treatment in either group （ P>0.05' .Both groups had a significant reduction in AMP and a significant increase in PD in the early stage of treatment （ 0-4 months）（ ⋅Z=2.05-3.92，P<0.05） ，followedby stable changes in 5-24 months.From enrollment to 24 months，there were no significant differences in the overall changes in AMP and PD between the two groups （Z=0.69-1.35，P>0.05） .ConclusionThis study shows that 0.2g/L atropine eye drops has a better effect than 0.1g/L atropine in controlling the progression of myopia，while the two treatment regimens have asimilarefectonAMPandPD.Bothconcentrationsofatropinecanefectivelycontroltheprogressonofmyopiaandaxialelongation simultaneously，with a similar annual control effect.

[Key words]myopia；atropine；refraction，ocular；axial length，eye； pupil； treatment outcome

近视的发病率在世界范围内显著增加，到2050年全球大约一半的人口将患有近视，而且高达 10% 的病例为高度近视[1]。（剩余8435字）