基于miR-146a-5p和miR-34a-5p的T2DM病人颈动脉粥样硬化预测模型构建

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[中图分类号] R587.1 [文献标志码] A[文章编号] 2096-5532（2025）04-0558-05

doi：10.11712/jms.2096-5532.2025.61.111

[Abstract]ObjectiveToinvestigate theassociationbetweentheexpressionlevels ofmiR-146a-5pand miR-34a-5pinserum andthedevelopmentofcarotid atherosclerosis（CAS）inpatients with type2diabetes melitus（T2DM），and toestablishapredictive model for CASin T2DMpatients.MethodsAtotalof 217 T2DM patients whoatended Anyang People's Hospital from January2022 toJanuary2024wereenroled.Relateddata werecolected，includingsex，age，body mass index，historyofhyper tension，smokinganddrinking，totalcholesterol，fastingbloodglucose，glycatedhemoglobin，homocysteine，triglyceride（TG）， low-densitylipoprotein（LDL），high-densitylipoprotein，andC-reactiveprotein，andtheserum levelsof miR-146a-5pand miR34a-5p were measured.Theinfluencing factorsfor CAS in T2DM patients wereanalyzed，anda nomogram prediction model for CAS in TDMpatients was established basedoninfluencing factors.ResultsThere were significant diferences between the CAS group andthe non-CAS groupinage，historyof hypertension，fasting blood glucose，TG，LDL，miR-146a-5p，and miR- 34a 5p （t=1.977-6.630，χ2=4.825，P<0.05） . The multivariate logistic regression analysis showed that age， fasting blood glucose， TG，LDL，miR-146a 5p ，and miR-34a-5p were independent influencing factors for the development of CAS in T2DM patients （ P<0.05 .The nomogram model had an area under the ROC curve of 0.849 95%CI=0.797-0.901） in predicting CAS in T2DM patients.The calibration curve andtheclinical decision curve showed thatthenomogram had good predictive performance. ConclusionThereare increases in the serum levelsof miR-146a-5pand miR-34a-5pin T2DMpatients withCAS，andthepredictive modelestablished basedontheserumlevelsof miR-146a-5pandmiR-34a-5phasgood predictive performanceforthedevelopment of CAS in T2DM patients.

[Key words]diabetes melitus，type 2；carotid artery diseases；circulating microRNA； forecasting；nomograms

2型糖尿病（T2DM）病人 80% 存在心血管疾病风险，颈动脉粥样硬化（CAS）是其重要标志和危险因素[1]。（剩余7890字）