慢性乙型肝炎病人血清HBVRNA检测及意义

打开文本图片集

[中图分类号] R446.1;R512.62 [文献标志码］A [文章编号] 2096-5532（2025）04-0516-04

doi：10.11712/jms.2096-5532.2025.61.130

[Abstract]ObjectiveToinvestigate thedeterminationand clinical significanceof serum hepatitis Bvirus （HBV）RNA in patients with chronic hepatitis B（CHB）．MethodsSerum HBVRNA was determined for 299 CHB patients，and HBV RNA， HBV DNA，HBsAg，HBeAg，and liver function parameters were compared between the HBeAg-negative group and the HBeAgpositive group and between the HBV DNA <20kU/L group and the HBV DNA ≥20kU/L group. A correlation analysis was also performed.ResultsTheHBeAg-positive grouphadasignificantlyhigher expresionlevelofHBVRNA thantheHBeAg-negative group ⋅Z=-12.448，P<0.001） ，with an HBV RNA positive rate of 82.10% in the HBeAg-negative group. The group HBV DNA ⩾20kU/L had a significantly higher expression level of HBV RNA than the HBV DNA <20kU/L group （ Z=-6.041，P< 0.001），with an HBV RNA positive rate of as high as 88.70% in the HBV DNA <20kU/L group. HBV RNA was positively correlated with HBsAg ， HBeAg ，and HBV DNA in both the HBeAg-positive group and the HBV DNA ⩾20kU/L group rs=0.481- 0.853，P<0.001 ）.Conclusion Serum HBV RNA determination complements the limitations of HBeAg and HBV DNA detection and can be used as an effective indicator for evaluating HBV replication.

[Key words]hepatitis B，chronic；hepatitis B virus；RNA，vira

慢性乙型肝炎（CHB）是全球重大公共卫生问题，2019 年导致约82万人死亡[1-2]。（剩余7129字）