RSV载量对AECOPD病人肺功能影响及与血清细胞因子关系

打开文本图片集

[中图分类号］R563.9 [文献标志码］A [文章编号] 2096-5532（2025）04-0578-05

doi：10.11712/jms.2096-5532.2025.61.134

[Abstract]ObjectiveTo study theeffects of respiratorysyncytial virus（RSV）loadonlung function in patients withacute exacerbationof chronicobstructive pulmonarydisease（AECOPD）and itsrelationship with serum cytokines.MethodsThis studyincluded 224patients withAECOPDadmitedtoour hospitalfromJune2018 toJune 2021.Theywere divided intohigh RSV load group ⋅n=132 ）andlow RSV load group ）.RSV-RNA load was measured using real-time quantitative PCR. Serum le vels of interleukin-6（IL-6），tumor necrosis factor- α （TNF- α ），and fibrinogen（FIB）were measured by chemiluminescence assay， enzyme-likedimmunosorbentassay，andthrombin timeassay，respectively.Forced expiratoryvolumeinthefirstsecond（FEV1） andthe ratioofFEV1/forced vital capacity（FVC）were measured using spirometry.ResultsCompared with the low RSV load group，the high RSV load group showed significantly higher serum levels of IL-6， TNF-α ，and FIB and significantly lower FEV1 and FEV1/FVC values Φt=4.443-12.051 ， .RSVload waspositively correlated with serum IL-6，TNF- α ，and FIB levels （r=0.391-0.487，P<0.05） and negatively correlated with FEV1 and FEV1/FVC r=-0.481，-0.477，P<0.05） . For evaluatingsevereireversibleairflowlimitationinpatients withAECOPD，theareasunderthereceiveroperatingcharacteristiccurvesof RSV load， IL-6 level，TNF- ⋅α level，FIB level，and the logistic model were 0.657，0.805，0.734，0.629，and 0.880，respectively. ConclusionIn patients with AECOPD，RSVload is related to the levels of serum cytokines，and has certain value in evaluating pulmonary function.

[Key words]pulmonary disease，chronic obstructive；respiratory syncytial viruses；respiratory function tests；cytokines

慢性阻塞性肺疾病（COPD）是一种全球范围内发病率和病死率较高的常见疾病]，其主要特征为持续性呼吸系统功能障碍和气流受限[2]。（剩余9672字）