急性白血病病人血浆PC、FVⅢ及血清PAI-1对预后的影响

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[中图分类号]R733.7 [文献标志码］A [文章编号] 2096-5532（2025）04-0563-05

doi：10.11712/jms.2096-5532.2025.61.136

[Abstract]ObjectiveToinvestigatetheefectsof plasma proteinC（PC）andcoagulationfactorV（FVl）andserum plas minogenactivator inhibitor-1（PAI-1）ontheprognosisofpatients withacuteleukemia.MethodsAtotalof304patients withacuteleukemiaadmited toourhospitalfromJanuary2020toJanuary2023wereincluded.Basedontheoutcomeofa2-yearfollowup，the patientswere dividedintosurviving group（58cases）and non-surviving group（246cases）.PlasmaPCandFanderum PAI-llevelswerecomparedbetweethetwogroups，andtheirpredictivevaluefortheprognosisofacuteleukemia within2years after discharge was evaluated.ResultsThe non-surviving group showed significantly lower plasma PC and FM levels （ ℓt= 4.842，4.491，P<0.05） anda significantly higher serum PAI-1 level than the surviving group （t=4.027，P<0.05） .PC，FV，and PAI-1 were independent prognostic factors for patients with acute leukemia（ P<0.05） .CombiningPC，FVIll，andPAI-1forpredictingthemortalityofpatientswithacuteleukemiawithin2yearsafterdischarge，theareaunderthereceiveroperatingcharacteristic curve（AUC）was O.828，which was significantly higher than the AUCs of individual indicators （Z=3.433-4.123，P<0.05） ： PC> （20 1.46mg/L ，FVI >103.15% ，and PAI- 1<116.26μg/L were associated with longer survival times （χ2=38.980-54.304，P< 0.001）．ConclusionThecombinationofPC，FVl，andPAI-1shows high predictivevaluefortheprognosisofpatients withacute leukemia.

[Key words] leukemia，acute；blood proteins；factor | ；plasminogen activator inhibitor；prognosis

急性白血病是一种造血干细胞的恶性克隆性疾病，发病率和死亡率均较高，病人预后较差，社会和家庭负担重[1-2]。（剩余7572字）