艾司西酞普兰联合脑电生物反馈对青少年抑郁症疗效

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[中图分类号]R749.41 [文献标志码］A [文章编号] 2096-5532（2025）04-0588-05

doi：10.11712/jms.2096-5532.2025.61.127

[Abstract]ObjectiveToinvestigatetheeficacyof escitalopramcombined withelectroencephalographicbiofeedback（EEG BF）inadolescentswithdepressionMethodsAtotalof04adolescentswithdepressionatthefirstepisode wererandomlyas signed in a 1：1 ratio to either study group （escitalopram + EEG-BF） or control group （escitalopram）. They were surveyed using the17-item Hamilton DepressionRating Scale（HAMD-17），Hamilton AnxietyRating Scale（HAMA），Chinese BriefCognitive Test （C-BCT），Pitsburgh Sleep Quality Index （PSQI），and Treatment Emergent Symptom Scale（TESS）before treatment and at theend of 2，4，6，and8 weeksof treatment.The two groups were comparedin terms of depresion score，anxietyscore，sleep score，cognitivefunction，incidenceofadversereactions，andoveral treatmentresponserate.ResultsTherewasasignificant maineffectofgroup，asignificantmainefctof time，andasignificant group-by-timeinteractionefectonHAMD-17，HAMA， and PSQI scores （Fgroup=6.995-21.606，Ftime=150.588-386.874，Finteraction=4.196-11.390，P<0.05） . The simple effect analyses showed that HAMD-17，HAMA，and PSQI scores in both groups were gradually decreased after treatment （ F=51.671- 192.476，P<0.01） . Since the endof the 4th week，the reductions in HAMD-17 score were significantly more pronounced in the study group than in the control group （t=6.084-26.115，P<0.05） . Since the end of the 2nd week，the study group showed significantly greater reductions in HAMA and PSQI scores than the control group （t=4.083-39.749，P<0.05） .By the end of the 8th week，comparedwiththecontrolgroup，thestudygroupexhibitedsignificantlyhigherC-BCTscoresintheinformationprocesing speed and attention dimensions （t=2.866，2.780，P<0.05） .The overall treatment response rate was significantly higher in the study group than in the control group （ χ2=27.094，P<0.01） . No significant differences regarding adverse reaction incidence rates were noted between the two groups （ ΔP>0.05） .ConclusionEscitalopram combined with EEG-BF can significantly improve depresion，anxiety，slpquality，and cognitive function among adolescents with depression，without increasing safetyrisks.

[Keywords] depressive disorder；escitalopram；neurofeedback；cognition；treatment outcome

我国 6～16 岁青少年抑郁症患病率高达 2.6% .已成为重大公共卫生问题。（剩余8175字）