氧化亚铜-壳聚糖-明胶止血抗菌敷料制备及性能评价

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[中图分类号] R618；R318.08 [文献标志码］A [文章编号] 2096-5532（2025）04-0475-08

doi：10.11712/jms.2096-5532.2025.61.105

[Abstract]ObjectiveTo prepare a wound dressing with rapid hemostasis and sustained antibacterial activity.Methods Cuprous oxide nanoparticles were mixedwith chitosan-gelatin（CG）solutionto preparecuprous oxide-chitosan-gelatin（CuCG） freze-dried spongeusingthefreeze-drying method.Aseriesofexperimentswereperformed toassessthephysicochemicalpropertiesofCuCGsponge，suchascoagulationtime，scannngelectronmicroscopyinfrared spectroscopy，swelingbehavior，waterre tentioncapacitycompresionstrength，ndantibacteralactivityRatmodelsofliverijuryndinfectedfullthickneskidefect wound wereusedtoobservethehemostaticandantibacterial efectsofCuCGspongeinuiuo，whichwascomparedwithchitosan （CS），and CG sponges.ResultsCompared with CSand CG sponges，CuCG sponge dressing had significantly higher porosity 1 ∵F=6.64，P<0.05） ，swelling rate （ F=6.07，P<0.05） ，and compression strength （ F=8.51，P<0.05） ，with good antibacterial activities against Sta phylococcus aureus （ F=475.80，P<0.001） and Escherichia coli（ F=73.36，P<0.001） .In uivo experiments showed thatcompared withthemedical gauzecontrol groupandtheCG sponge group，theCuCG grouphad significantlybetter time to hemostasis （ F=4.68，P<0.05 ）andbleeding volume （F=16.16，P<0.01） for liver injury in rats，and on days 7 and 14， there was a significant diference in would healing rate between the CuCG group and the other two groups （ ′F=5.13，4.72，P< 0.05）.Conclusion The novel CuCG dressing prepared in this study has good hemostatic and antibacterial effects，and therefore， it has a potential application value in war，natural disaster，and other situations.

[Key words] copper；chitosan；gelatin；bandages；materials testing；hemostasis

因局部战争、自然灾害等导致的军人及民众开放性创伤时有发生[。（剩余12301字）