解郁丸联合盐酸舍曲林治疗青少年抑郁症临床研究

打开文本图片集

[中图分类号］R748.4 ［文献标志码］A [文章编号]0256-7415（2025）14-0101-04

DOl：10.13457/j.cnki.jncm.2025.14.019

Clinical Study of Jieyu Pills Combined with Sertraline Hydrochloride in Treating Adolescent Depression

LIU Liya，LYU Yuanxin，LIANG Guihua，PAN Feng，LUO Dingxiang，HUI Hongxing YulinVeterans Hospital，Yulin Guangxi 5370oo，China

Abstract：Objective：To observe the clinical effect of Jieyu Pills combined with Sertraline Hydrochloride in treating adolescent depression.Methods：Atotal of8O first-onset adolescent depression patients admited to Yulin Veterans Hospitalfrom January 2O23 to January 2024 were selectedanddivided into thecontrol groupandthe trial group using therandom number table method，with4O cases in each group.Thecontrol group receivedoral Sertraline Hydrochloride Tablets，while the trial group received Jieyu Pils in adition to Sertraline Hydrochloride.Both groups were treated for four weeks.The clinical effects，relative power of neurotransmitters[ 5- hydroxytryptamine（5-HT）， norepinephrine （NE），dopamine（（DA）]，scores of Hamilton Depression Scale（HAMD），and scores of Treatment Emergen Symptom Scale（TESS）were compared between the two groups before and aftertreatment.Results：The total effective rate was 95.00%（38/40） in the trial group and 77.50% （31/40） in the control group，the difference being significant between the two groups （ P<0.05 ）. After treatment，HAMD scores were decreased in both groups when compared with those before treatment （ P<0.05 ），with the trial group showing lower HAMD scores than the control group （ P<0.05 ）.After treatment，the relative power of 5-HT，NE，and DA were increased significantly in both groups （ P<0.05 ），with higher relative power observed in the trial group compared to the control group （ P<0.05 ）. The incidence of adverse reactions during treatment was 2.50%（1/40） in the trial group and 17.50% （7/40）in the control group，the difference being significant （ P<0.05 ）.Conclusion：Jieyu Pills combined with Sertraline Hydrochloride improves clinical efect in treating adolesent depresson，significantly alleviates depressive symptoms，enhances neurotransmitter relative power， and reduces adverse reactions.

Keywords：Adolescent depresion；Jieyu Pils；Sertraline Hydrochloride；Relative power of neurotransmitters; Hamilton Depression Scale

抑郁症为青少年常见精神疾病，病因复杂，具体机制尚不清楚，主要临床特征为显著而持久的心境低落，病程长，复发率高，终生患病率达 11%～ 20% ，严重影响患者学业、人际关系和社会功能。（剩余4077字）