益脑温胆汤治疗轻度认知障碍临床研究

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[中图分类号］R749.1 [文献标志码］A [文章编号]0256-7415（2025）14-0054-05

DOl：10.13457/j.cnki.jncm.2025.14.011

Clinical Study on Yinao Wendan Decoction in the Treatment of Mild Cognitive Impairment

LIHongjuan，HUANGHongqiang，CHENXiaolin

TheSecondAfiliated HospitalofGuangzhou Universityof Chinese Medicine，Guangzhou Guangdong 51Oo06，China

Abstract：Objective：To observe the clinical eficacy of Yinao Wendan Decoction in the treatmentof mild cognitive impairment （MCI）.Methods：A total of 7O patients with MCI who admited to the outpatients of Memory Disorders Clinic and hospitalized in Geriatrics Department of Higher Education Mega Center Hospital，Guangdong Provincial Hospital of Chinese Medicinewere selected from December 2022 to July2024，and were divided into 35cases eachin the control group and the study group according to the random number table method.Thecontrol group was given oral administrationof Donepezil Hydrochloride Tablets，andthe study group was treated with Yinao Wendan Decoction.After12 weeksof treatment，theclinical efcacy inthetwo groups was compared，as wellas thechanges in the scores of the Mini-Mental State Examination（MMSE），Montreal Cognitive Assessment （MoCA），and Activities of Daily Living Scale（ADCS-ADL）before and after treatment.Results：After treatment，the total effective rate was （20 80.00% （28/35）in the study group and 57.14% （20/35）in the control group，the difference being statistically significant （ P<0.05 ）.After treatment， the scores of MMSE and MoCA in the two groups were increased when compared with those before treatment （ P<0.05 ）， the ADCS-ADL score in the study group was increased when compared with that before treatment （ P<0.05 ），and the scores of MMSE，MoCA，and ADCS-ADL in the study group were higher than those in the control group（ ⌈P<0.05 ）.The Cibic-plus scores in the two groups were decreased when compared with those before treatment （ ⋅P<0.05 ），and the Cibic-plus score in the study group was lower than that in the control group （ P<0.05 ）.Conclusion：Yinao Wendan Decoction in the treatment of MCI can enhance the clinical effcacy，improve thecognitive functionandactivitiesofdailyliving of patients，andtheeffctissuperiorto thatof Donepezil treatment.

Keywords：Mild cognitive impairment；Yinao Wendan Decoction；Mini-Mental State Examination；Montreal Cognitive Assessment；Activities ofDaily Living Scale

轻度认知障碍（MCI）是从正常认知衰老到早期痴呆连续体中的中间状态。（剩余7016字）