基于数据挖掘技术总结李宗智治疗脑小血管病伴视网膜微血管病变用药规律

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[关键词］脑小血管病；视网膜微血管病变；中医传承计算平台；李宗智；用药规律 [中图分类号］R277.7 ［文献标志码］A [文章编号］0256-7415（2025）12-0007-06 DOI：10.13457/j.cnki.jncm.2025.12.002

Summary of LI Zongzhi's Medication Rules in Treating Cerebral Small Vessel Disease with Retinal Microangiopathy Based on Data Mining Technology

CHEN Yuxiao¹，XIA Gaofu²，CAI Jing³ 1.GuizhouUniversityofTraditionalChineseMedicine，GuiyangGuizhou50o25，China；2.DepartmentofNeurology，TheAffliated BaiyunHospitalofGuzhouMedicalUniversity，GuiyangGuizhou55O4，China；3.DepartmentofEncephalopathy，TheFisffliaed Hospital of Guizhou Universeity of Traditional Chinese Medicine，Guiyang Guizhou 55ooo1，China

Abstract：Objective：Toanalyze Profesor LI Zongzhi's medication rules for cerebral small vessel disease（CSVD）with retinal microangiopathy using the Traditional Chinese Medicine Inheritance Computing System（V3.5）.Methods：Medical records of CSVD patientswith retinal microangiopathy treated by Professor LI Zongzhi from September 202O to March 2O23 were collcted.Herb usage frequency，natures，flavors，and channel entries were analyzed via the System，along with asociation rules and cluster analyses for core prescriptions.Results： A total of 539 prescriptions involving 122 herbs were included. High-frequency herbs （ >300 times）in descending order were Lophatheri Herba，Casiae Semen，Paeoniae Radix Alba，Puerariae Lobatae Radix，Ligustri Lucidi Fructus， and Uncariae Ramulus cum Uncis.Herb natures were predominantlycold and cool，flavors sweet and biter，with the fot-jueyin liverchannelasthe primarychannel entry.Deficiency-replenishing and heat-eliminating herbswere frequently utilized.Association rules analysis identified 32 combinations with confidence ⩾0.98 .Cluster analysis yielded six core novel prescriptions， two with >100 uses：Lophatheri Herba， Cassiae Semen，Paeoniae Radix Alba， Forsythiae Fructus，Lycii Fructus，Pittosporum ilicioides Makino，Puerariae Lobatae Radix and Tribuli Fructus; Cassiae Semen，Lophatheri Herba，Paeoniae Radix Alba，Ligustri Lucidi Fructus，Uncariae Ramulus cum Uncis， Puerariae Lobatae Radix，Cuscutae Semen and Dioscoreae Rhizoma.Conclusion：Professor LI Zongzhi's treatment emphasizes clearing liver and nourishing yin for CSVD with retinal microangiopathy，prioritizing clearing heat over supplementing deficiency， supplemented by clearing the heart.

Keywords：Cerebral smallvessel disease；Retinal microangiopathy；Traditional Chinese Medicine Inheritance Computing System；LI Zongzhi；Medication rules

脑小血管病（CSVD）是一组渐进性发展、可累及颅内诸多微小血管的临床、影像、病理综合征，主要表现为运动障碍、认知障碍等。（剩余5933字）