热休克蛋白家族H1的生物学功能及疾病相关性

DOI：10.16424/j.cnki.cn32-1807/r.2025.05.020

[中图分类号]R34 [文献标志码]A [文章编号] 1674-7887（2025）05-0502-04

Biological functionsand disease relevance of heat shock protein family H1*

JI Yuelong**，YU Guangdong，YUAN Conghu*** （Department of Anesthesiology， Affiliated Hospital 6 of Nantong University， the Yancheng Third People's Hospital， Jiangsu ）

[Abstract]Theheatshock proteinfamilyH1（HSPH1）isamolecularchaperonethatplaysakeyprotectiveroleincels，particularlyinresponse toenvironmentalstressandinmaintaining protein homeostasis.Inrecentyears，theHSPH1proteinhas atractedmuchetinfoisprgresinrietyfseassspeiallyceurodegeetieisasdadios cular diseases.Incancerresearch，HSPH1 has been found to promote the growth and survival of tumorcels.In neurodegenerative diseases，HSPH1has been show to preventthe acumulationof misfolded proteins，which isamajorpathological featureof diseasessuchasParkinson’sdisease.Inaddition，HSPH1playsan important protectiveroleincardiovasculardisease. Inthefuture，we shouldcontinue to studythe mechanismandfunctionof HSPH1indepth to provide asmanynew strategies as possible for the treatment of various diseases.

[Key Words]heat shock protein familyH1;cancer; neurodegenerativedisease;cardiovasculardisease;treatmentstrategy

热休克蛋白家族 H1（heat shock protein family H1，HSPH1）是热休克蛋白家族H（HSP110）的成员之一，也被称为HSP105。（剩余10709字）