合并肝损伤的初治肺结核患者临床特征及治疗效果分析

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DOI：10.16424/j.cnki.cn32-1807/r.2025.05.003

[中图分类号]R521 [文献标志码]A [文章编号]1674-7887（2025）05-0422-04

Analysis of clinical characteristics and therapeutic effect of newly diagnosed pulmonary tuberculosispatientscombined with liver injury*

QUShengyan*，XUFeifan** （Department of Clinical Laboratory， the Sixth People's Hospital of Nantong，Jiangsu 226011） [Abstract]Objective：Toinvestigatetheclinical characteristicsand therapeuticefectof newlydiagnosedpulmonary tuberculosiscombinedwith liver injury.Methods：109 patientswithnewlydiagnosedpulmonary tuberculosis fromJanuary 2022 toDecember 2O24basedonobvious tuberculosisetiologydiagnosed intheSixth People's Hospitalof Nantong were selected.According to whethercombined with liver injury in hospitalized，theywere divided into liver injury group（ n =50）and non-liver injury group n =59）.The clinical general data，liver function and pathogen test results，anti-tuberculosis treatment results and other indicatorsof thetwo groups were retrospectively analyzedand compared.Results：The levelsof ALT，AST andtotalbilirubininthe liver injury group were significantlyhigherthan those in thenon-liver injurygroup（all P<0.05 5）. There was no significant differencein the level of direct bilirubinbetween the two groups（ P> 0.05）.The proportion of high and medium GeneXpertRIFresults inthe liverinjury groupwassignificantlyhigherthanthatinthenon-liver injury group（34.00%vs1.86 % （204号 36.00% Vs 16.95% ，both P<0.05 ） and the ratio of pulmonary cavities was also higher than that in the non-liver injury group C 36.00% vs 10.17% P<0.05 ）. During the treatment，the anti-tuberculosis time was prolonged（ P =0.008 3），the negative conversion rate was significantly lower than that of the non-liver injury group（8o.OO% vs 96.61 % P =0.009 2）and the negative conversion time was significantly longer[（47.12±9.19） d vs （21.93±19.07） d， P<0.000 1]，which was prone to treatment failure. Conclusion： NewlydiagnosedpulmonarytuberculosispatientscombinedwithliverinjuryhavehigherMycobacteriumTuberculosiscounts， more tuberculouscavitiesinthelungsandprolongedanti-tuberculousistimeduringthetreatment，whichiseasilytocause treatment failure.These patients should be paid more attention in clinical.

[KeyWords]pulmonarytuberculosis; liver injury;anti-tuberculosis therapy;clinical characteristic;therapeuticffect

虽然结核病的研究已较为深人，但结核感染仍是影响全球人类健康的重大传染病之一。（剩余7478字）