纳洛酮联合瑞芬太尼注射剂用于宫颈癌根治术老年患者的临床研究

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[Abstract]ObjectiveToinvestigatetheclinical efectof naloxonecombinedwithremifentanil injectioninelderlypatients undergoingradicalhysterectoyforcervicalcancer，andtoevaluateitsfectonpostoperativepaincontrol，recoveryquaityandadversedrugreactions.MetodsAtotalof1O2elderlypatientsounderwentradicalhysterectoyforcervicalcanceratHuangshiMaternityandChildHealthHospitalofHubeiProvincefromJanuaryO23toDecember2O24wereenroled，theywererandomlydivided intoatrialgroupandacontrolgroupusingarandomnumbertable，with51patientsineachgroup.Thecontrolgroupreceivedconventionalremfentanilinjectionforanesthsiamaintenanceuringsurgery，hiletetrialgoupreceivedsalldosenaloxoneombied withemifentanil.Allpatientsrceivedthesamepostoperativeanalgesiaregimenndpostoperativepaiwasaessedusingtevisual analogscale（VAS）.Recovery im，extubation time，adversedrugreactions，andserumindicators，including norepinephrine（NE）， epinephrine（Epi），cortisol（Cor），monocytechemoatractantprotein-1（MCP-1），andglutathioneperoxidase（GSH-Px）levelswere recorded forcomparison.ResultsThetrialgrouphadshorterrecoverytimeandextubation timecomparedtothecontrol group（ P< 0.05）.Postoperatively，the VAS scores of the trial group were lower than those of the control group （ P<0.05 ）.Theserumlevelsof MCP-1，GSH-Px，NE，Epi，and Cor were also lower in the trial group than in the control group（ P<0.05 ）.The incidences of agitation，nausea/vomiting，and bradycardia of the trial group were lower than those of the control group （ P<0.05 ）.No significant differences were found inthe incidencesof hypertension，respiratorydepression，orurinaryretention betweenthe twogroups（ P>0.05 ） ConclusionNaloxonecombiedwithremifentanilinjectioefectivelyallviatespostoperativepinshortensrecoerytim，anddemonstrates good safety in elderly patients undergoing radical hysterectomy for cervical cancer.

[Key words] Naloxone；Remifentanil；Radical hysterectomy for cervical cancer；Postoperative Pain；Recovery quality

宫颈癌是女性常见的癌症之一，在老年女性中的发病率较高[1]。（剩余8462字）