老年脑胶质瘤患者术后疲乏与免疫炎性标志物水平的相关性研究

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[Abstract]ObjectiveTo explore thecorrelation betweenthe severityof postoperativefatigue（POF）and the levels of immuneandinflammatorymarkersinelderlypatients withgliomas.MethodsAtotalof12Oelderlypatientswith glomaswhounderwent surgeryfromJanuary2022toSeptember2O24wereenrolldinthisstudyTheseverityofpostoperativefatiguewasasessedusingthe Cancer-relatedfatigueselfrtingscale（CFS）onte7thpostoperativeday.Acodingtoteevauationesults，45patientsweredivided into mild fatigue group （CFS ⩽3 points），50 into moderate fatigue group（CFS 4～6 points）and 25 into severe fatigue group （CFS ⩾7 points）．Serum immune markers[CD4/CD8*Tcellratio，natural kilercell（NK）activity]and inflammatory markers [C-reactiveprotein（CRP），interleukin-6（IL-6）]weredetectedonthe7thpostoperativedayPearsoncorelationanalysiswas usedtocomparethediffrencsadcoelaionsmongtheteegrous.ResultsOnetaaftrsurgeytatisticallysiificant differences were observed among the three patient groups in terms of serum CD4+/CD8 + T cell ratio，NK activity，CRP levels，and IL6 levels （ P<0.05 ）.Compared with the mild fatigue group，the moderate fatigue group had lower CD4 ↓+ /CD8 + T cell ratio，NK activity，and higher CRP and IL-6 levels，and the diference was statistically significant （ P<0.05 ）； compared with the mild fatigue group and the moderate fatigue group，the severe fatigue group had lower CD4 + /CD8 + T cell ratio，NK activity，and higher CRP and IL-6 levels，and the difference was statistically significant （ P<0.05 ）.Pearson correlation analysis showed that POF score was negatively correlated with CD4+/CD8+ T cell ratio and NK activity （ P<0.05 ）and positively correlated with CRP and IL-6 levels （ P<0.05 ）.

ConclusionTheseverityofpostoperativefatigueinelderlypatientswithglomasiscloselyelatedtoimmunefunctionandinflamato rymarkers.Patientswithseverefatigue havesignificantlydecreasedimmunefunctionand increased inflammatoryresponse.

[Keywords] Glioma；Postoperative fatigue；Immune indicators；Inflammatorymarkers 姜程，等．老年脑胶质瘤患者术后疲乏与免疫炎性标志物水平的相关性研究

脑胶质瘤作为一种中枢神经系统中最常见的恶性肿瘤，其高侵袭性和复发率使患者的生存质量受到严重影响。（剩余8422字）