康欣口服液对衰老大鼠氧化应激和肠道菌群的影响

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[Abstract]ObjectiveThisstudy preliminarily discussedtheanti-aging mechanism of KangxinOral Liquid by studying its efectsonoxidativestresandintestinalflora inagingrats.MethodsTheagingratmodelwasestablishedbyD-galactoseinduction， andKangxinOralLiquidwasgivenbygavageatthesametime.Thebodyweightwasmonitoredandtheindexesofthebrain，spleen， liverandkidneywere measured.The levelsofsuperoxidedismutase（SOD），malondialdehyde（MDA）andeactiveoxygenspecies （ROS）inserum and organs were measured.Theefectof Kangxinoraliquidonthechanges in gut microbiotacausedbyaging was studiedby16SRNAsequencing.Tecorelationbetweeintestinalfloraandoxidativestress indexesasaalyzedResultsKangxin oralliquidcouldsignifcantlyincreasethebodyweightandorganindexofagingrats，reducethelevelsofoxidativestressfactosser umandrgans，ncreasetheabundanceofbeneficialbacteriassuchasPseudoflavonifractorandRuminococcaceae，educethebundancefharmfulbacteriassuchasClostridialesandmaintainthehomeostasisofaging-relatedgutmicrobiota；theabundanceofClostridiales，PseudoflavonifrctorandRuminooccceaewassiificantlyelatedwithSOD，DAandROSlevels.ConclusionKangin Oral Liquidcan anti-aging by reducing oxidative stress injuryand regulating intestinal microbial changes.

[Keywords] Kangxin Oral Liquid；Aging；D-galactose；Oxidative stress；Gut microbiota

衰老指随时间推移，机体在多个层面逐渐发生的功能衰退与适应能力下降的现象。（剩余15240字）