急性呼吸衰竭合并肺部感染老年患者血清单核细胞 趋化蛋白-1、肽素的变化

打开文本图片集

[Abstract]ObjectiveToexplore theclinical significanceofchanges inserumlevelsof monocytechemoatractantprotein-1 （MCP-1）andcopeptininelderlypatientswithacuterespiratoryfailurecomplicatedbypulmonaryinfection.MethodsAtotalof12 elderlypatientswithacuterespiratoryfailurewereadmitedtoourhospitalfromJanuaryO21toJanuaryO23wereselectedastestudy subjects.Theywere dividedintoaninfected group（132cases）andanoninfectedgroup（8Ocases）basedonwhetherpulmonary infectionccured.ELISAmethodasapliedtodetectthelevelsofserum MCP-1andcopeptin.Pulmonaryfunctiontesterwasusedto measure forcedvitalcapacity（FVC）andforced expiratoryvolumeinonesecond（FEV1）.Patients intheinfectiongroupwerefollowedupfor1yearanddividedintopoorprognosisgroup（79cases）andgoodprognosisgroup（53cases）according totheprogosis. Pearsoncorrelationwasaplied toanalyzetherelationshipbetweenserumMCP-1，copeptinlevelsandlungfunction indicators.ROC curvewasapliedtoanalyzethepredictivevalueofserum MCP-1andcopeptinforpoorprognosisinelderlypatientswithacuterespiratoryfailurecomplicatedwithpulmonaryinfection.ResultsThelevelsofMCP-1andcopeptinintheserumoftheinfectedgroupwere higher than those in the non infected group （ P<0.05 ）. The levels of FVC and FEV1 in the infected group were lower than those in the non infected group （ P<0.05 ）. The serum MCP-1 and copeptin levels in elderly patients with acute respiratory failure were negatively correlated with FVC and FEV1 levels （ P<0.05 ）.The levels of MCP-1 and copeptin in the serum of the poor prognosis group were higher than those of the good prognosis group（ P<0.05 ）.TheAUC of predictingpoorprognosis in elderlypatientswith acute respiratoryfailurecomplicatedbypulmonaryinfectionbythecombinationofserumMCP-1andcopeptinishigherthanthepredictivepowerof the two indicators alone （ P<0.05 ）.ConclusionMCP-1，copeptin levels are highly expressed in the serum of elderly patients with acuterespiratoryfailureandpulmonary infection，andbothareexpected to become monitoring indicatorsfordiseaseprognosis.

[Key words] Acute respiratory failure；Pulmonary infection；Monocyte chemoatractant protein-1；Copeptin

大多数急性呼吸衰竭患者在7d内会出现新发或恶化的呼吸道症状[1]。（剩余8524字）