《血液储存标准》对冷沉淀和新鲜冰冻血浆解冻后储存条件修改的研究

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中图分类号：R331.1 文献标识码：A

Abstract Objective To investigate thechanges in cryoprecipitate and fresh frozen plasma （FFP）after thawing due to modifiedstorageconditionsandtovalidatetherationalityof therevisions madetotheBloodStorageStandard.MethodsAtotalof 48 bags each ofcryoprecipitate andFFPpreparedfromOctober 2023 to August 2024at theNanjingRed Cross Blood Center wererandomlyselectedAftercomplete thawing，cryoprecipitate wasstoredunderfourconditions：4Cfor6hours，4Cfor24hours，24C for 6 hours，and 24∘C for 24 hours. The changes in fibrinogen（ Fbg⋅ ，coagulation factor VIII （FVIl），coagulation factor V（FV）， andcoagulationfactorII（FII）contentincryoprecipitateunderdiffrentconditionswerecompared.Aftercompletethawing，FFP was stored at 4∘C for 24 hours and 4∘C for l20 hours. The changes in total protein （TP），Fbg，FVIl，，FV，and FII content were compared.ResultsAfter thawing，cryoprecipitate was stored under the four conditions. Compared with the initial F M content， the F M content decreased under all four conditions. The differences in F M content between the conditions of 4∘C for 6 hours， 4∘C for 24 hours，and 24∘ C for 24 hours and the original test results were statistically significant （ P<0.05 ）. After thawing， FFP was stored at 4∘C for 24 hours and 4∘C for l20 hours.There were no statistically significant differences in TP and Fbg content compared with O hours after thawing （ P>0.05 ）. The content of FVIll，FV，and FII decreased，and the differences were statistically significant （ P （20 <0.05 ）.ConclusionAfter the revision of the Blood Storage Standard（ ：WS399-2023∣ ，cryoprecipitate demonstrates better clinical efficacy，and FFP can be better utilized in clinical treatment while reducing waste.

Key words Blood Storage Standard;Cryoprecipitate;Fresh Frozen Plasma;Blood Quality; Blood Safety First-authorsaddress Nanjing Red Cross Blood Center，Nanjing，Jiangsu，2looO3，China

冷沉淀是由全血分离出的新鲜冰冻血浆（约 200mL 制备而成的白色絮状物。（剩余7934字）