中医药防治糖皮质激素性骨质疏松症的研究进展

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【中图分类号】R285.5 【文献标志码】A 【文章编号】1007－8517（2025）16-0061-04

DOI： 10.3969/j .issn.1007-8517.2025.16. zgmzmjyyzz202516013

Research Progress of TCM in the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis

ZHAN Yanhong1ZHANG Zhizhong1*XIE Zhijun² 1.FourProvincial Marginal Hospital ofTraditional ChineseMedicineAfiliatedto ZhejiangChinese Medicine University，Quzhou 32400O，China； 2. Zhejiang Hospital of Traditional Chinese Medicine，Hangzhou 31Oooo，China

Abstract：Over theyears，glucocorticoidshavebeenwidelyused inclinicalpractice，andosteoporosisisthemostcommonerious complicationAtpresent，avarietyof singleChinesemedicinesandcompound preparationshavebeenfoundtoactonosteoblasts and osteoclasts through the expression of Wnt/ β -catenin，OPG/RANK/RANKL，BMPs and other signaling pathways and related geneproteins，thusfectingtheprocessofboneformationandboneabsoption，whichprovidesstrongevidenceforthepreventionand treatmentofGIOPbyChinesemedicine.Thispaperdiscusss thepathogenesisofGIOP，theconceptofTCMandtheprogresofpre ventionandtreatmentofTCM，soastoletthemajorityofclinicalworkersknowaboutGIOPandatractatentiontothedisease.

Keywords：GlucocorticoidOsteoporosis；Traditional Chinese Medicine；Pathogenesis；SignalingPathways；ResearchProgress

糖皮质激素（glucocorticoids，GC）作为风湿免疫疾病、过敏性疾病的常用药，被广泛应用于临床治疗当中，然而长期大量使用会导致一系列不良反应，其中最常见，也最容易忽视的即糖皮质激素性骨质疏松症（glucocorticoid-inducedoste-oporosis，GIOP），超过 50% 的风湿免疫性疾病患者在长期接受激素治疗中出现骨质疏松的不良反应[1]，同时也发现许多长期使用GC的患者从未使用抗骨质疏松的药物。（剩余8575字）