不同剂量利伐沙班治疗老年心力衰竭合并房颤患者的临床效果及安全性对比

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中图分类号：R541.6；R541.7+5 文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.13.028 文章编号：1006-1959（2025）13-0142-04

Abstract：OjectieTsudtelicalfndsfetyofdifeentdosofaroabainetreamentoflderlypatientswihartfalure andatrialiliesol2trlirtflcdralr hospitalweredividedintoacontrolgoupandanobservationgroup（29casespergoup）usingaandomumbertablemethod.Thecontrolgroup received rivaroxaban with a dose of 20mg/d ，while the observation group received rivaroxaban with a dose of 10mg/d .Theclinical efficacy，cardiac functionineatdeeofdactddefdosdebovstsd betweenhetgouResultshrsatisallysiiiantdieineotaletivatefrmntetwtoos（ P> （20 0.05）.TheefttruarjetiofrctonLVEFoftetogousasertantatforetreamntndedstoliceftriclar posterior wallthickness（LVPWD） was lower than that before treatment（ PΦ <0.05），but there wasno statistically significant difference inLVEFand LVPWD between the two groups after treatment（ P>0 0.05）.The D-dimer（D-D）of the two groups was lower than that before treatment，and the prothrombitsoert）utsatistllteid two groups after treatment（ P>0.05 ）.Theincidences of adversereactionsand cardiovascularandcerebrovascular events intheobservationgroup were bothlowerthantoseinthotrolgoupPO5）.Cocusioneliicaletsoffretdossofivaroabanintetreamntfelderly patientswitartedloallpeduodedlatioo However， 10mg/d rivaroxabanhasfeweradversereactionsandlowerincidenceofcardiovascularandcerebrovascularevents，ndhasrelativelybetter treatment safety.

KeyWords：Differentdoses;Rivaroxaban;Elderly;Heartfailure;Atrial fibrillation;Safety

心力衰竭（heartfailure）是临床常见的疾病，其发生与多种因素相关[]，而房颤（atrialfibrillation）是心力衰竭常见的并发症之一，会加重病情，增加心脑血管不良事件发生率，严重威胁患者生命安全。（剩余5054字）