不同剂量布地奈德雾化吸入对老年慢性阻塞性肺病急性加重期患者的治疗效果观察

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中图分类号：R563 文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.13.018 文章编号：1006-1959（2025）13-0098-05

Abstract：ObjectieTvestigatetetrapeuticetofdieretossofudesodeforoslilaoolderlypatintswihute exacerbationofonicstructiveumoarydiseaseMetodsUsingteadommbertablemetodotalyOderlyatientsithcute exacerbationofhocbstructiepulmoarydiseasedmitedtouichangCountyeoplesHospitalduringtheperiodfroJanuarytJay 2024wereandlylaedtoooodnsdoachsisgofatintseodoreatioal dose（mg/ti）fdesodespsioforalatiodtdoastreatediose（tsofdesodespr inhalationecalacngcodeatoeined（FEV）dialapacit expiratory flow （PEF）]，inflammatory factors [interleukin- ⋅8 （IL-8），tumor necrosis factor -a （TNF-a），procalcitonin （PCT）]，immune function （CD3 + ， CD4CD8s ResultsCompdioptdodigealsoseatesellsvelsfVVCEVVd after treatment （P<0.05）.The levels of IL-8，TNF- α ，and PCT were lower in the study group than those in the control group P<0.05） .Additionally， the study group showed significantly higher CD 3+ ，CD 4+ ，andCD4+/CD8 ζ+ levels，and lower CD8 + levels than those in the control group （P<0.05）. No statistically significant diference was observed in adverse reaction rates between the groups（ P >0.05）.Conclusion High-dose（2 mg/times） budesonideforoslialatioisetiveintraetofdelatitsituteecebatioofocructieulmoasese whichcapengidoftsetosefdceio It is worthy of clinical application.

KeyWords：Diferentdose;Budesonide;Aerosolihalation;Elderly;Acuteexacerbationofchronicbstructivepulmonarydiseae

慢性阻塞性肺病急性加重期的病情发展速度较快，而且容易反复发作，对患者的生命安全造成了严重的威胁，且该病具有较高的致残率和致死率，对患者和家属都是一种沉重的负担。（剩余5740字）