基于孟德尔随机化方法分析炎症性肠病与牙周炎的因果关系

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关键词：孟德尔随机化；牙周炎；炎症性肠病；基因变异

中图分类号： R781.4+2 ；R574 文献标识码：A DOI：10.3969/j.issn.1006-1959.2025.13.017 文章编号：1006-1959（2025）13-0094-04

Abstract：ObjetiveTvestigateeualelatiosetwnflamatowelsase（DdprodotiDbysigdel randomization.eodseargalegeoewideociatioudy（WAataofteEuroeanederatioofPerootoload theInteatioalIatoowelDiosorreedTigleedpSod withperiodontitseredsstrutalvaableely6d686.Atoapleethsedtoalyte causalrelatiosetodoiisdKfsdefoaliotrodeprocesofdata The MR-egger method was used to estimate the causal effect of periodontitis on IBD.The Cochran's Q test and F statistics were used to evaluate the consistencyotasulealotid the risk of IBD （OR=1.18，95 % CI1.09-1.28，P<0.oo1）.Theestimationresultsofcausal effectof differentSNPswerebasicallyconsistent（Q=0.41， P =0.52， F =0）.ConclusionsTheMendelianrandomizationstudyconfimedthecausalasociationbetweeperiodonitisandinflammatoryowel disease，providinganewperspectiveforunderstanding thepathogenesisandpreventionstrategiesof thesetwodiseases.

Keywords：Mendelian randomization;Periodontitis; Inflammatory bowel disease; Gene variation

牙周炎（periodontaldisease，PD）是一种由牙菌斑生物膜引起的牙周组织慢性感染性疾病，可导致牙周支持组织的破坏如牙槽骨、牙周膜、牙骨质和牙龈的炎症、退缩和丧失，是造成牙齿脱落的主要原因[2。（剩余7935字）