鹰潭市男性不育患者Y染色体微缺失和外周血染色体核型分析联合研究

打开文本图片集

[Abstract] Objective：To investigate Y chromosome microdeletion and peripheral blood chromosome karyotypeof male infertilitypatientsin Yingtan City.Method：Theclinical dataof92maleinfertilitypatients admitedtoYingtan CityPeople's Hospital fromJuly2O23 to July2O24 wereretrospectivelyanalyzed，allpatients were given routine physical examination，Ychromosome microdeletion and peripheral blood chromosome karyotype  examination.The Y chromosome microdeletion and abnormal chromosome karyotype and phenotype of male infertility patientswere analyzed.Result： In 92 male infertility patients，11 cases （11.96% ）were found with Y chromosome microdeletion by Y chromosome microdeletion examination，including 2 cases with cryptorchidism and 2 cases with varicocele.In 92 male infertility patients，17 cases （18.48% ）were found to have abnormal karyotypes by chromosome karyotype examination. Conclusion： Chromosome abnormality and tiny deletion of Y chromosome account forarelatively high proportion of male infertilitypatients，which is the main genetic factor，through chromosome examination and Y chromosome deletion detection，it can effectively prevent blind treatment and reduce therisk of genetic diseases，providing ideas for clinical treatment ofmale infertility.

[Keywords] SterilityMaleY chromosome microdeletion Peripheral blood Chromosome karyotype

First-author'saddress：Department ofNuclearMedicine，Yingtan City People'sHospital，Yingtan 335000， China

doi：10.3969/j.issn.1674-4985.2025.23.037

男性不育是指由于男性生殖系统功能障碍或其他原因导致伴侣无法受孕，可能由多种因素引起，包括生殖器感染、精索静脉曲张、精子生成障碍、激素水平异常等[]。（剩余5568字）