胞磷胆碱钠联合瑞舒伐他汀对脑小血管病认知障碍患者认知功能与运动功能的影响

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[Abstract] Objective： To investigate the effects of Citicoline Sodium combined with Rosuvastatin on cognitive function and motorfunction in patients with cognitive impairment of cerebral small vessel disease. Method：A totalof2OOpatients withcognitiveimpairmentofcerebral smallvesseldiseaseadmitedtoDepartment of Neurology，Tongliao People's Hospital from January 2O2 to January 2O24 were selected astheresearchobjects. The patients were divided into two groups by random number table method.The treatment plan forthe control group （ n ：100）wasoral Citicoline Sodium，while the observation group （n=1OO）was treated with Rosuvastatin on the basis of thecontrol group.Thecognitivefunction，motorfunction，communicationability，motionalstate，qualityoflifeand dailyliving ability were compared between the two groups.Result：Thecognitive function，qualityoflife，anddaily living abilityof theobservation group after8and12 weeks ofintervention were beterthan thoseof thecontrol group （P<0.05） .After12 weeks of intervention，the upper and lower limb motor function scores of the observation group werehigher than those ofthe control group，while the communication function scores，depresionandanxiety scores werelower than those of the control group P<0.05 ）.Conclusion：Citicoline Sodium combinedwith Rosuvastatin can improve the cognitive function of patients with cognitive impairment of cerebral smallvessel disease，which is beneficial to the improvement of motor function and the quality of life of patients.

[Keywords] Citicoline Sodium Rosuvastatin Cerebral small vessel diseaseCognitive impairment

First-author'saddress：DepartmentofNeurology，TongliaoPeople'sHospital，TongliaoO28ooo，China doi：10.3969/j.issn.1674-4985.2025.23.014

脑小血管病是因脑内小动脉及其远端分支、微动脉、微静脉等小血管病变引起的一系列临床、病理、影像综合征。（剩余6061字）