盐酸硫必利片联合芍麻止痉颗粒对儿童抽动 障碍的影响

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[Abstract]Objective： To evaluate the clinical eficacy Tiapride Hydrochloride Tablets combined with Shaoma Zhijing Granulesintreating children with ticdisorders.Method：Thisprospective，randomized controlled trial wasconductedat fromFebruary 2O22 to July 2O24，involving 102 children with tic disorders.Participants were randomly divided into control group （51 cases）and an experimental group （51 cases）ata 1：1 ratio.The control group received Tiapride Hydrochloride Tablets treatment，while the experimental group received a combination Tiapride Hydrochloride Tablets and Shaoma Zhijing Granules.Tic symptoms [Yale global tic severity scale （YGTSS）score]，traditional Chinese medicinesyndrome scores，behaviorand intellgence [Achenbach childbehaviorchecklist （CBCL）score andWechsler intelligence scale for children score]，the levels neurotransmiter [dopamine （DA）， norepinephrine （NE），and brain-derived neurotrophic factor （BDNF）]，and adverse reactions （loss appetite，dizziness and fatigue，drowsiness，rash，diarrhea） were compared between the two groups.Result： After treatment，the experimental group showed lower YGTSS scores and traditional Chinese medicine syndrome scores than the control group （P<0.05） . The experimental group also had lower CBCL score and higherWechsler inteligence scale scores than the control group （P<0.05） ）.ThelevelsDAandNE were lower，while BDNFlevels were higher in the experimental group compared to the control group （ P<0.05） .The total rate adverse reactions in the experimental group was lower than that in the control group （P<0.05 ）.Conclusion：The combined use Tiapride Hydrochloride Tabletsand Shaoma Zhijing Granules in treating children withtic disorders isefective in improving tic symptoms，behavior and inteligence performance，andoptimizing neurotransmitter levels，while reducing adverse reactions， it isa safe and effective treatment option.

[Keywords]Tiapride Hydrochloride TabletsShaoma Zhijing GranulesChildren with tic disorders Neurotransmitter levels

First-author'saddress：Department Child Health Care，， 342500， China

doi：10.3969/j.issn.1674-4985.2025.23.003

儿童抽动障碍是一种以突发性、快速、重复的运动或发声为特征的神经精神疾病，常见于儿童及青少年[]。（剩余5805字）