卡瑞利珠单抗联合同步放化疗治疗中晚期食管鳞癌的效果

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Effect of Camrelizumab Combined with Concurrent Chemoradiotherapy in the Treatment of Middle and Advanced Esophageal Squamous Cell Carcinoma/GU Guangfu，LI Caihong.//Medical Innovationof China，2025，22（18）：135-138

[Abstract] Objective： To explore the clinical effect of Camrelizumab combined with concurrent chemoradiotherapy in patients with middle and advanced esophageal squamous cellcarcinoma. Method： A total of 80 patients diagnosed with middleand advanced esophageal squamous cell carcinoma and admitted to the Second Affiliated Hospital of Xuzhou Medical University from May 2O2O to April2024 were selected.The patients were randomly divided intothe observation group and thecontrol group bythe computer digital table method，with 40 cases in each group. The control group received concurrent chemoradiotherapy，while the observation group was treated with Camrelizumabonthe basis ofthe control group.Theclinical eficacy，serum tumor markerlevels and the occurence of adverse reactions between the two groups were compared. Result： The disease control rate and objective effectiveratein theobservationgroup were both higherthan those inthecontrol group，the diferences were statisticallysignificant（ P <0.05）.After18 weeks of treatment，the levels of serum tumor markersin the observation group were all lower than those in the control group，the differences were statistically significant （ P- <0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （ P >0.05）. Conclusion：For middle and advanced esophageal squamous cellcarcinoma patients，the addition of Camrelizumab treatment onthebasis of concuirent chemoradiotherapycanachieve satisfactory results，reducethe levels of serum tumormarkers，and hasarelatively high treatment safety.

[Key words]CamrelizumabConcurrent chemoradiotherapyEsophageal squamous cellcarcinoma

First-author'saddress： Radiotherapy Department， the Second Affiliated Hospital of Xuzhou Medical niversity，Xuzhou221006，China

doi：10.3969/j.issn.1674-4985.2025.18.031

食管癌也称为食道癌，是源自食管上皮组织的恶性肿瘤，主要病理类型为鳞癌。（剩余5729字）