失眠障碍过度觉醒的功能神经影像学证据

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Functional Neuroimaging Evidence for Hyperarousal in Insomnia Disorder/LONG Jinhao， LIN Qianglong， LIU Junbin， TIAN Junzhang. /Medical Innovation of China， 2025， 22（12）： 174-179

[Abstract]Insomnia disorder （ID） is the most common sleep disorder， which seriously endangers people's quality oflife andphysicaland mentalhealth.There isnounifiedconclusionon its pathogenesis，and hyperarousal is themain theory to explain thepathogenesis of ID at present.Thedevelopment of neuroimaging enables it to study the brain mechanism at thefunctionallevel.Thisreviewaims to clarify the evidence of hyperarousal in function and metabolism of IDpatients by integrating the existing functionalneuroimaging studies.Although theresults are different，mostofthemshow thatID patientshave experienceda state ofhigh excitement，andthese findings support that hyperarousal plays a key role in the pathophysiology of ID.In thefuture， we should clarify the mechanismof hyperarousalinthe wholediseaseprocessthrough longitudinal research and promote the application of neuroimaging in ID diagnosis and prognosis evaluation.

[Key words] Insomnia disorder Hyperarousal Functional neuroimaging

First-author's address： Department of Nuclear Medicine， the Afiliated Guangdong Second Provincial General Hospital of Jinan University， Guangzhou 510317， China doi： 10.3969/j.issn.1674-4985.2025.12.042

失眠障碍（insomniadisorder，ID）被定义为一种频繁且持续的睡眠起始或维持困难、早醒且难以再次人睡，伴有明显的日间功能受损。（剩余16556字）