新型抗血小板药物替格瑞洛与阿司匹林在脑梗死二级预防中的对比研究

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Comparative Study Ticagrelor Novel Antiplatelet Drug and Aspirin in Secondary Prevention Cerebral Infarction/YANG Wei， LI Ping， WU Youhao， FAN Wenfeng， WANG Tianzhong. //Medical Innovation China， 2025，22（12）： 001-005

[Abstract]Objective： To explore the effct Ticagrelor novelantiplateletdrug and Aspirin in secondary prevention cerebralinfarction.Method：A total 124 patients withcerebral infarction admitted to ， Zhongxiang People's Hospital from March 2020 to January 2022 were selected and divided into experimental group （ n =62） and control group （n=62） according to random envelope method. The control group was treated with Aspirin，and the experimental group was treated witha novelantiplatelet drug Ticagrelor.Cognition and limb function， platelet aggregation rate，cerebral bloodperfusion parameters and recurrence were compared between the two groups.Result： After 6 months treatment， the scores mini-mental state examination （MMSE） and Fugl-Meyer assessment （FMA）increased inbothgroups，theplatelet aggregationrateatland5mindecreased， and the scores MMSEandFMA inthe experimental groupwerehigher than those inthecontrol group，theplatelet aggregation rate at 1 and 5 min were lower than those in control group （ P <0.05）. After 6 months treatment， total cerebral blood flow increased， blood flow velocity middlecerebral artery （MCA）accelerated and the average passage time shortened in both groups， and total cerebral blood flow in experimental group was greater than that in control group，blood flow velocity MCA was faster than that in control group，and the average passage time was shorter than that in control group （ P <0.05）. The recurrence rate experimental group was 6.45% ， which was lower than 19.35% control group （ P <0.05）. Conclusion： In secondary prevention cerebral infarction， Ticagrelor has a significant effect， which can significantly reduce the platelet agregation rate，improve cerebral blood perfusion， improve cognition and limb function patients， and prevent cerebral infarction recurrence.

脑梗死是一种严重的神经系统疾病，其为大脑动脉系统发生动脉粥样硬化或血栓形成，使动脉管腔狭窄或闭塞，从而造成血管内血流受阻，引起脑组织坏死、缺血与软化的缺血性脑卒中-2]。（剩余5253字）