连续性血液净化、血浆置换辅助治疗噬血细胞性淋巴组织细胞增生症患儿的效果

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Effect of Continuous Blood Purification Plasmapheresis in the Adjuvant Treatment of Hemophagocytic Lymphohistiocytosis/GE Xiaofeng， NI Jia， TANG Rong. //Medical Innovation of China， 2025，22（12）： 005-008

[Abstract]Objective： To analyze the effect of continuous blood purification plasmapheresis in the adjuvant treatment ofhemophagocyticlymphohistiocytosis （HLH）.Method：A totalof 50children withHLH treated in from January to December 2023 were selected as the study objects divided into two groups according to rom number table method.The control group received basic treatment， the observation group received continuous blood purification plasmapheresis onthe basis ofthe control group.The clinicalefficacyinterleukin-6 （IL-6），interleukin-10（IL-10），interleukin-12（I-12）the incidenceofcomplications werecomparedbetween thetwo groups.Result：Thetotalefectiverateoftheobservation group was 88.00% ， which was higher than 60.00% of the control group， the difference was statistically significant =5.094， P =0.024）.After 4 weeks of treatment， the levels of IL-6， IL-10 IL-12 in the observation group were lower than those in the control group， the differences were statistically significant （ P<0.05） .The total incidence of adverse reactions in the observation group was 16.00% ， which was lower than 48.00% in the control group， the difference was statistically significant （ P=0.015 ）. Conclusion： Continuous blood purification

① 贵阳市妇幼保健院儿童重症医学科贵州贵阳550001 通信作者：葛晓风

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plasmapheresis have good effct intheadjuvanttreatmentof HLHchildren，whichcan significantlyreduce thelevels of inflammatory factors reduce the incidences of complications.

[Key words] Continuous blood purification Plasmapheresis Chemotherapy Hemophagocytic lymphohistiocytosis Complication

First-author's address： Department of Intensive Medicine， Maternal ， 550001， China doi：10.3969/j.issn.1674-4985.2025.12.002

噬血细胞性淋巴组织细胞增生症（hemophagocyticlymphohistiocytosis，HLH）是一种有潜在致命性的免疫调节障碍疾病，其特征是免疫系统过度激活，导致炎症细胞过度增生和活化，进而影响多个器官系统。（剩余5415字）