度拉糖肽对2型糖尿病合并肝硬化患者血糖 水平、肝硬化指标的影响

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Effects of Dulaglutide on Blood Glucose Levels and Liver Cirrhosis Indexes in Patients with Type 2 Diabetes Mellitus Complicated with Liver Cirrhosis/ ， ， ， ， .//Medical Innovation of China， 2025， 22（12）： 013-016

[Abstract]Objective：To analyzethe effcts of Dulaglutide on blood glucose and liver cirrhosis indexes in patients with type 2diabetes mellitus.Method：A total of 80patients with type2diabetes melltus complicated withliver cirrhosis admitted to Ganzhou Fifth People's Hospital from January to December 2022were selected as the study objects， and they were divided into control group and observation group by random drawing method， with 40 cases in eachgroup.The control groupwas treated with insulin，and the observation groupwas treated with Dulaglutideonthe basisof the controlgroup.Blood glucose andlivercirrhosis index were compared between the two groups.Result： Onthe 30th， 90th and18Othdays oftreatmentand1 year after treatment， the fasting blood glucose （FBG） and 2 h postprandialblood glucose （2 h PBG）levels inthe observation group were lower than those in the control group， the differences were statistically significant （P<0.05 ）. On the 18Oth days of treatment and 1 year after treatment，theliver stiffness measurement（LSM）of theobservation group werelowerthan those of the control group， the differences were statistically significant （P<0.05） . Conclusion： Dulaglutide can improve blood glucose levels and

基金项目：江西省卫生健康委科技计划项目（202511103）

① 赣州市第五人民医院肾内内分泌科江西 赣州341000

② 赣州市第五人民医院精神科江西赣州 341000通信作者：邓鹏

liver function in patients with type 2 diabetes mellitus complicated with liver cirrhosis.

[Key words] Dulaglutide Type 2 diabetes melitus Liver cirrhosis Blood glucose Liver stiffness measurement

First-author's addres： Department of Nephroendocrine， Ganzhou Fifth People's Hospital， Ganzhou 341000， China

doi：10.3969/j.issn.1674-4985.2025.12.004

2型糖尿病是由多种原因导致机体内胰岛素分泌不足或胰岛素利用障碍，导致机体血糖水平持续高于正常范围，损伤机体血管、神经等，危害心、肝、肾等器官功能的内分泌性疾病[1-2]。（剩余4551字）