慢性阻塞性肺疾病合并骨质疏松的相关研究进展

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Research Progress on Chronic Obstructive Pulmonary Disease Complicated with Osteoporosis/ Kalibinuer Yisilamu， Kelibiena Tuerxun， Manzila Yasen. //Medical Innovation of China， 2025， 22（11）： 178-184

[Abstract]Chronic obstructive pulmonary disease （COPD） is a kind of common multiple diseases characterized byventilation restriction， which mainly occurs inmiddle-aged and elderly people.Osteoporosis is a common complicationof COPD.The significantfeature of osteoporosis is that due to changes inthe microstructure of bone tissue，bonemassdecreases，resulting in increased fragilityofbone，thereby increasing theriskof fracture. Fractures caused by osteoporosis may increase morbidity and mortality in patients with COPD and lead to further deterioration of lung function. Therefore， COPD is closely related to osteoporosis. COPD patients have a high incidence of osteoporosis，which may be associated with systemic inflammation， corticosteroid use， vitamin D deficiency， physical inactivity， tobacco exposure， decreased bone mineral density，hypogonadism，hypoxia，and anemia.Inclinical practice，the rate of diagnosis and treatmentof osteoporosis in patients with COPD is low.Bone mineral density is aquantitative indexused todiagnoseand predictosteoporosis and evaluatethe efficacy of drug therapy.However， due tothe slow process of bone mineral densitychange，bone metabolismindicators can be used as a sensitive reference to measure the severity of osteoporosis.

[Key words] Chronic obstructive pulmonary disease Osteoporosis Bone metabolism Vitamin D Lung function

First-author's address： Respiratory Center of the First Affiliated Hospital of Xinjiang Medical niversity， Urumqi 830054， China doi： 10.3969/j.issn.1674-4985.2025.11.040

慢性阻塞性肺病全球倡议（GOLD）将慢性阻塞性肺疾病（COPD）定义为一种以持续气流受限为特征的进行性疾病。（剩余13881字）