四君子汤加减结合FOLFOX4方案化疗对晚期 结直肠癌患者血清肿瘤标志物水平、KPS 评分的影响

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Effect of Modified Sijunzi Decoction Combined with FOLFOX4 Regimen Chemotherapy on Serum Tumor Marker Levels and KPS Score in Patients with Advanced Colorectal Cancer/XIAO Lu， YI Yanfei， ZHONG Huan， WANG Zhiqiang，XIAO Wei， LUO Nengping.//Medical Innovation of China， 2025， 22（11）： 026-029

[Abstract]Objective： To analyze the effect of modified Sijunzi Decoction combined with FOLFOX4 chemotherapy on patients with advanced colorectalcancer.Method： A total of 60 patients withadvancedcolorectal cancer admitted to Ganzhou Cancer Hospital from January 2022 to December 2023 were randomly divided into two groups， with 30 patients in each group.The control group received FOLFOX4 regimen chemotherapy， and the observationgroupreceivedmodified SijunziDecoctiontreatmentonthebasis ofthecontrol group，allofwhich were treated for 4courses.The clinicalefficacy，tumor markers，immune function，healthstatusandincidenceof adverse reactions were compared between thetwo groups.Result：The totalefective rate of treatment in observation group washigherthanthat incontrol groupandthe incidenceofadversereactions waslowerthanthat incontrol group，the differences were statistically significant （ <0.05）. After treatment， carcinoembryonic antigen （CEA）， carbohydrate antigen 125 （CA125），carbohydrate antigen199（CA199），CD8+in observation groupwerelower thanthose in control group， while CD ，CD4 and Karnofsky functional status rating scale （KPS） score were higher than those in control group，thediffrences were statisticallysignificant （P<0.O5）.Conclusion：Modified SijunziDecoction combined with FOLFOX4 regimen chemotherapy can inhibit the proliferation of cancer cells in advanced colorectalcancer patients， improve immunity， improve health level， and less adverse reactions.

[Key words] Advanced colorectal cancer Sijunzi Decoction Tumor markers Immune function Adverse reactions

结直肠癌为临床多发的恶性肿瘤，存在较高的发病率与致死率。（剩余5243字）